Synthesis of Tetrahydroberberine N,N-Derived O-Acetamides

Synthesis of Tetrahydroberberine N,N-Derived O-Acetamides Full article

Journal

MolBank
ISSN: 1422-8599

Output data

Year: 2024, Number: 3, Article number : M1865, Pages count : DOI: 10.3390/M1865

Tags

berberine; berberubine; tetrahydroberberine; tetrahydroberberrubine; acetamides

Authors

Nechepurenko Ivan Vasil’evich ¹ , Komarova Nina Ivanovna ¹ , Salakhutdinov Nariman Faridovich ¹

Affiliations

1	Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, Russia

The reaction of berberine derivatives containing at the O-9 position N,N-disubstituted acetamide fragments with sodium borohydride in methanol at 0 °C leads to a mild reduction of the “C” cycle with the formation of corresponding tetrahydroberberine derivatives with moderate to good yields.

Nechepurenko I.V. , Komarova N.I. , Salakhutdinov N.F.
Synthesis of Tetrahydroberberine N,N-Derived O-Acetamides
MolBank. 2024. N3. M1865 . DOI: 10.3390/M1865 WOS Scopus OpenAlex

Submitted:	Jul 10, 2024
Accepted:	Aug 6, 2024
Published online:	Aug 13, 2024

Web of science:	WOS:001326054900001
Scopus:	2-s2.0-85205301832
OpenAlex:	W4401584696

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