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Antioxidant activity of synthetic analogs and pure active principles of rhodiola rosea and raspberry ketone Научная публикация

Журнал Pharmaceutical Chemistry Journal
ISSN: 0091-150X , E-ISSN: 1573-9031
Вых. Данные Год: 2012, Том: 45, Номер: 12, Страницы: 732-735 Страниц : DOI: 10.1007/s11094-012-0713-4
Ключевые слова antioxidants; tyrosol; analogs; alpha-tocopherol; structure modification
Авторы Storozhok N. M. 1 , Gureeva N. V. 1 , Khalitov R. A. 1 , Storozhok A. S. 1 , Krysin A. P. 2
Организации
1 (Данные Web of science) Tyumen State Med Acad, Tyumen, Russia
2 (Данные Web of science) Russian Acad Sci, Vorozhtsov Inst Organ Chem, Siberian Branch, Irkutsk 664003, Russia

Реферат: The antioxidant action of natural tyrosol derivatives, raspberry ketone, and their synthetic analogs was studied in comparison with alpha-tocopherol and butylhydroxytoluene. It is shown that hydroxylation of tyrosol increases the antioxidant activity 1.5 times. The introduction of one o-tert-butyl substituent increases the inhibiting action by a factor of 3.5; of two o-tert-butyl substituents, by greater than 4.0 times. The maximum inhibiting effect was observed for tert-butylhydroxytyrosol, the structural modification of which included simultaneously both hydroxylation and alkylation. The antioxidant activity of the studied substances was lower than that of alpha-tocopherol and butylhydroxytoluene. It was established that the induction periods of the studied antioxidants (AOs) in addition to many natural inhibitors (alpha-tocopherol, carotenoids, flavonoids) as functions of the concentrations of the studied AOs exhibit peaks. Thus, directed structural modifications of natural compounds yielded new effective oxidation inhibitors, the application of which will probably avoid undesired effects related to overdoses of the existing drugs.
Библиографическая ссылка: Storozhok N.M. , Gureeva N.V. , Khalitov R.A. , Storozhok A.S. , Krysin A.P.
Antioxidant activity of synthetic analogs and pure active principles of rhodiola rosea and raspberry ketone
Pharmaceutical Chemistry Journal. 2012. V.45. N12. P.732-735. DOI: 10.1007/s11094-012-0713-4 WOS Scopus РИНЦ OpenAlex
Даты:
Опубликована в печати: 1 мар. 2012 г.
Опубликована online: 13 апр. 2012 г.
Идентификаторы БД:
Web of science: WOS:000303534900008
Scopus: 2-s2.0-85027956811
РИНЦ: 41779885
OpenAlex: W2038260422
Цитирование в БД:
БД Цитирований
Web of science 7
Scopus 8
РИНЦ 6
OpenAlex 7
Альметрики: