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Synthetic transformations of sesquiterpene lactones. V.* Synthesis and cytotoxicity of 13-aryl-substituted tourneforin derivatives Full article

Journal Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388
Output data Year: 2012, Volume: 48, Number: 2, Pages: 245-249 Pages count : 5 DOI: 10.1007/s10600-012-0214-4
Tags tourneforin; Heck reaction; 13-aryleudesmanolides; tumor cells; XSA
Authors Shul'ts E.E. 1 , Patrushev S.S. 1,2 , Belovodskii A.V. 1 , Shakirov M.M. 1 , Rybalova T.V. 1 , Pokrovskii A.G. 2 , Pokrovskii M.A. 2 , Tolstikov G.A. 1 , Adekenov S.M. 3
Affiliations
1 (Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
2 (Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
3 (Данные Web of science) Int Sci Prod Holding Fitokhimiya, Karaganda 100009, Kazakhstan

Abstract: 13-Aryl-substituted tourneforin derivatives were synthesized via the Heck reaction with aryliodides. The structure of (E)-13-(3,4-dimethoxybenzyl)-eudesma-4(5),11(13)-dien-6 alpha,12-olide was confirmed by an XSA. A study of the cytotoxicity of the synthesized derivatives for CEM-13, MT-4, and U-937 tumor models showed promise for the modification.
Cite: Shul'ts E.E. , Patrushev S.S. , Belovodskii A.V. , Shakirov M.M. , Rybalova T.V. , Pokrovskii A.G. , Pokrovskii M.A. , Tolstikov G.A. , Adekenov S.M.
Synthetic transformations of sesquiterpene lactones. V.* Synthesis and cytotoxicity of 13-aryl-substituted tourneforin derivatives
Chemistry of Natural Compounds. 2012. V.48. N2. P.245-249. DOI: 10.1007/s10600-012-0214-4 WOS Scopus РИНЦ OpenAlex
Dates:
Published print: May 1, 2012
Published online: May 16, 2012
Identifiers:
Web of science: WOS:000304651800017
Scopus: 2-s2.0-85027919658
Elibrary: 41777147
OpenAlex: W2028251223
Citing:
DB Citing
Web of science 5
Scopus 2
OpenAlex 4
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