The Analgesic Activity of 8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepine-6-amine and Its Hydrochloride Full article
| Journal |
Letters in Drug Design and Discovery
ISSN: 1570-1808 , E-ISSN: 1875-628X |
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| Output data | Year: 2012, Volume: 9, Number: 5, Pages: 513-516 Pages count : 4 DOI: 10.2174/157018012800389296 | ||
| Tags | Analgesic activity; Benzopentathiepine; Acetic acid-induced writhing test; Hot plate test; Opioidergic system | ||
| Authors |
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Abstract:
8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepine-6-amine 1a and its hydrochloride revealed significant analgesic activity in the acetic acid-induced writhing test, and ED50 of the compound 1a was 0.66 mg/kg. In the hot plate pain test, the reliable analgesic activity was found in hydrochloride 1a*HCl, whereas the free base 1a proved to be inactive. Based on the results of the naloxone test, the analgesic effect of the compound 1a*HCl in both tests is mediated with the opioidergic system. Both the free base 1a and its hydrochloride did not show the anti-inflammatory activity. Replacement of the CF3 group for the fluorine atom resulted in complete loss of analgesic activity in the acetic acid-induced writhing test.
Cite:
Tolstikova T.G.
, Pavlova A.V.
, Morozova E.A.
, Khomenko T.M.
, Volcho K.P.
, Salakhutdinov N.F.
The Analgesic Activity of 8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepine-6-amine and Its Hydrochloride
Letters in Drug Design and Discovery. 2012. V.9. N5. P.513-516. DOI: 10.2174/157018012800389296 WOS Scopus РИНЦ OpenAlex
The Analgesic Activity of 8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepine-6-amine and Its Hydrochloride
Letters in Drug Design and Discovery. 2012. V.9. N5. P.513-516. DOI: 10.2174/157018012800389296 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Apr 26, 2012 |
Identifiers:
| Web of science: | WOS:000308667300010 |
| Scopus: | 2-s2.0-84860762141 |
| Elibrary: | 17984830 |
| OpenAlex: | W2735543072 |