Influence of Usnic Acid and its Derivatives on the Activity of Mammalian Poly(ADP-ribose)polymerase 1 and DNA Polymerase beta Full article
| Journal |
Medicinal Chemistry
ISSN: 1573-4064 , E-ISSN: 1875-6638 |
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| Output data | Year: 2012, Volume: 8, Number: 5, Pages: 883-893 Pages count : DOI: 10.2174/157340612802084225 | ||||
| Tags | DNA Polymerase beta; PARP1; Poly(ADP-ribose)polymerase; Usnic acid | ||||
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Abstract:
The influence of a number of usnic acid derivatives on auto(polyADP-ribosyl)ation catalyzed by PARP1 and DNA synthesis catalyzed by DNA polymerase beta was studied. The derivatives of usnic acid containing aromatic substituents were shown to be moderate inhibitors of PARP1. The presence of both usnic acid tricyclic structure and aromatic substituent at any position of the molecule is a key factor for the inhibitory action. In the case of DNA polymerase, no relationship between the structure and inhibitory properties has been found with the only exception. Derivatives with modified ring A showed mild activation of DNA synthesis catalyzed by DNA polymerase beta.
Cite:
Zakharenko A.
, Sokolov D.
, Luzina O.
, Sukhanova M.
, Khodyreva S.
, Zakharova O.
, Salakhutdinov N.
, Lavrik O.
Influence of Usnic Acid and its Derivatives on the Activity of Mammalian Poly(ADP-ribose)polymerase 1 and DNA Polymerase beta
Medicinal Chemistry. 2012. V.8. N5. P.883-893. DOI: 10.2174/157340612802084225 WOS Scopus РИНЦ OpenAlex
Influence of Usnic Acid and its Derivatives on the Activity of Mammalian Poly(ADP-ribose)polymerase 1 and DNA Polymerase beta
Medicinal Chemistry. 2012. V.8. N5. P.883-893. DOI: 10.2174/157340612802084225 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Sep 1, 2012 |
Identifiers:
| Web of science: | WOS:000309650400014 |
| Scopus: | 2-s2.0-84865739563 |
| Elibrary: | 20473542 |
| OpenAlex: | W2314968626 |