Effect of Triterpene Derivatives on the Total Hepatocyte Count in the Liver of Rats with Toxic Hepatitis Full article
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Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888 |
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| Output data | Year: 2012, Volume: 153, Number: 6, Pages: 859-862 Pages count : DOI: 10.1007/s10517-012-1844-z | ||||
| Tags | toxic hepatitis; triterpene derivatives; heptral; biochemical markers; hepatocyte count | ||||
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Abstract:
We studied hepatoprotective activity of betulonic acid and its alaninamide on the model of combined CCl4- and ethanol-induced toxic liver damage in rats. The test substances, especially betulonic acid alaninamide, considerably reduced the elevated biochemical parameters in animals with toxic liver damage. Betulonic acid alaninamide also stimulated reparative processes in the liver (activated hepatocyte proliferation). Heptral (reference drug) produced no appreciable effects on the reparative processes. Our findings suggest that betulin derivatives exhibit pronounced protective properties.
Cite:
Semenov D.E.
, Zhukova N.A.
, Bessergeneva E.P.
, Sorokina I.V.
, Baev D.S.
, Glukhov B.M.
, Nepomnyaschikh G.I.
, Tolstikova T.G.
Effect of Triterpene Derivatives on the Total Hepatocyte Count in the Liver of Rats with Toxic Hepatitis
Bulletin of Experimental Biology and Medicine. 2012. V.153. N6. P.859-862. DOI: 10.1007/s10517-012-1844-z WOS Scopus РИНЦ OpenAlex
Effect of Triterpene Derivatives on the Total Hepatocyte Count in the Liver of Rats with Toxic Hepatitis
Bulletin of Experimental Biology and Medicine. 2012. V.153. N6. P.859-862. DOI: 10.1007/s10517-012-1844-z WOS Scopus РИНЦ OpenAlex
Original:
Семенов Д.Е.
, Жукова Н.А.
, Бессергенева Е.П.
, Сорокина И.В.
, Баев Д.С.
, Глухов Б.М.
, Непомнящих Г.И.
, Толстикова Т.Г.
Влияние тритерпеновых производных на общую численность гепатоцитов в печени крыс с токсическим гепатитом
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2012. Т.153. №6. С.837-840. РИНЦ
Влияние тритерпеновых производных на общую численность гепатоцитов в печени крыс с токсическим гепатитом
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2012. Т.153. №6. С.837-840. РИНЦ
Dates:
| Published print: | Oct 1, 2012 |
| Published online: | Nov 1, 2012 |
Identifiers:
| Web of science: | WOS:000310811000014 |
| Scopus: | 2-s2.0-84875586349 |
| Elibrary: | 20482194 |
| OpenAlex: | W2022105583 |