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Antiviral Activity of 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol and its Derivatives Against Influenza A(H1N1)2009 Virus Full article

Journal Letters in Drug Design and Discovery
ISSN: 1570-1808 , E-ISSN: 1875-628X
Output data Year: 2011, Volume: 8, Number: 4, Pages: 375-380 Pages count : 6 DOI: 10.2174/157018011794839411
Tags Monoterpenoids; para-menthane; Nicotinate; Influenza; Pandemic; Antiviral
Authors Ardashov Oleg V. 1 , Zarubaev Vladimir V. 2 , Shtro Anna A. 2 , Korchagina Dina V. 1 , Volcho Konstantin P. 1 , Salakhutdinov Nariman F. 1 , Kiselev Oleg I. 2
Affiliations
1 Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russian Federation
2 Department of Chemotherapy, Influenza Research Institute, 15/17 Prof. Popova St., 197376 St. Petersburg, Russian Federation

Abstract: A number of new derivatives of monoterpenoid with a para-menthane framework 3-methyl-6-(prop-1-en-2-yl) cyclohex-3-ene-1,2-diol (-)-3 were synthesized. The antiviral activity of (-)-3 and its derivatives against the pandemic influenza virus A/California/07/09 (H1N1)v was studied in vitro. Compound (-)-3 was found to be active against this virus (selectivity index 7.5); for mononicotinate (+)-6 the selectivity index was 17. The absolute configuration of compound 6 was shown to be critical for its antiviral activity.
Cite: Ardashov O.V. , Zarubaev V.V. , Shtro A.A. , Korchagina D.V. , Volcho K.P. , Salakhutdinov N.F. , Kiselev O.I.
Antiviral Activity of 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol and its Derivatives Against Influenza A(H1N1)2009 Virus
Letters in Drug Design and Discovery. 2011. V.8. N4. P.375-380. DOI: 10.2174/157018011794839411 WOS Scopus РИНЦ OpenAlex
Dates:
Published print: May 1, 2011
Identifiers:
Web of science: WOS:000290905200011
Scopus: 2-s2.0-79955952679
Elibrary: 16995543
OpenAlex: W2331197780
Citing:
DB Citing
Web of science 18
Scopus 18
Elibrary 19
OpenAlex 18
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