Inclusion Complexes of Nitroxides of Pyrrolidine and Imidazoline Series with Cucurbit[7]uril Full article
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Journal of Physical Chemistry B
ISSN: 1520-6106 |
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| Output data | Year: 2010, Volume: 114, Number: 4, Pages: 1719-1728 Pages count : 10 DOI: 10.1021/jp9103678 | ||||||
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Abstract:
Inclusion of nitroxides into the Cavity of molecular nanocontainers may prevent or significantly retard nitroxide reactions with Cellular reductans and increase nitroxide lifetime. This paper is aimed Lit studying possible applications of cucurbit[7]uril (CB7) as a nanocontainer for pH-sensitive nitroxides probes. Inclusion complexes of CB7 with different nitroxides-3-aminomethyl-proxyl (AMP), 3-hydroxymethyl-proxyl (HMP), 4-amino-2,2,5,5-tetramethyl-2,5-dihydroimidazole-1-oxyl (ATI), and 2,2,4,5,5-pentamethyk-2,5-dihydroimidazole-1-oxyl (MTI)(-)were studied. It was found that reversible formation Of inclusion complexes AMP@CB7, AMPH(+)@CB7, HMP@CB7, ATIH(+)@CB7, and MTIH+@CB7 is accompanied by a decrease of hyperfine interaction (HFI) constant oil nitrogen of the nitroxide group and by a 5-7-fold increase of rotational correlation time monitored by electron paramagnetic resonance (EPR). The binding constants of nitroxide@CB7 complexes were determined, and the influence of alkali metal ions and pH on the equilibrium between free and encapsulated nitroxides Was Studied. The EPR spectra of CB7 mixtures with protonable nitroxides were found to be more sensitive to pH changes than the spectra of pure nitroxides, and the apparent pK of these mixtures was found to increase with CB7 concentration. The nitroxide@CB7 complexes showed higher resistance to chemical reduction with ascorbic acid compared to free nitroxides. Thus, CB7 call be used for the improvement of functional properties of nitroxides.
Cite:
Kirilyuk I.
, Polovyanenko D.
, Semenov S.
, Grigor'ev I.
, Gerasko O.
, Fedin V.
, Bagryanskaya E.
Inclusion Complexes of Nitroxides of Pyrrolidine and Imidazoline Series with Cucurbit[7]uril
Journal of Physical Chemistry B. 2010. V.114. N4. P.1719-1728. DOI: 10.1021/jp9103678 WOS Scopus РИНЦ OpenAlex
Inclusion Complexes of Nitroxides of Pyrrolidine and Imidazoline Series with Cucurbit[7]uril
Journal of Physical Chemistry B. 2010. V.114. N4. P.1719-1728. DOI: 10.1021/jp9103678 WOS Scopus РИНЦ OpenAlex
Dates:
| Published online: | Jan 7, 2010 |
| Published print: | Feb 4, 2010 |
Identifiers:
| Web of science: | WOS:000273947900023 |
| Scopus: | 2-s2.0-75749095190 |
| Elibrary: | 15329715 |
| OpenAlex: | W1983653992 |