Nitroxyl Antioxidant TPPA-TEMPO Increases the Efficacy of Antitumor Therapy on the Model of Transplantable Mouse Tumor Full article
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Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888 |
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| Output data | Year: 2010, Volume: 150, Number: 1, Pages: 75-78 Pages count : DOI: 10.1007/s10517-010-1073-2 | ||||||
| Tags | LS lymphosarcoma; therapy; cyclophosphamide; nitroxyl radicals; TPPA-TEMPO | ||||||
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Abstract:
Nitroxyl antioxidant 4-triphenylphosphonioacetamido-2,2,6,6-tetramethylpiperidine-1-oxyl (TPPA-TEMPO) was synthesized from 4-chloroacetamido-2,2,6,6-tetramethylpiperidine-1-oxyl chloride and triphenylphosphine. Systemic administration of TPPA-TEMPO in the subtoxic dose to mice with lymphosarcoma inhibited tumor growth, but did not prolong animal lifespan. Combined treatment with TPPA-TEMPO and cyclophosphamide increased the efficacy of antitumor therapy: it prolonged animal lifespan and increased the number of recovered mice.
Cite:
Kirilyuk I.A.
, Kaledin V.I.
, Popova N.A.
, Nikolin V.P.
, Vasil'eva E.D.
, Grigor'ev I.A.
, Lushnikova E.L.
, Nepomnyashchikh L.M.
Nitroxyl Antioxidant TPPA-TEMPO Increases the Efficacy of Antitumor Therapy on the Model of Transplantable Mouse Tumor
Bulletin of Experimental Biology and Medicine. 2010. V.150. N1. P.75-78. DOI: 10.1007/s10517-010-1073-2 WOS Scopus РИНЦ OpenAlex
Nitroxyl Antioxidant TPPA-TEMPO Increases the Efficacy of Antitumor Therapy on the Model of Transplantable Mouse Tumor
Bulletin of Experimental Biology and Medicine. 2010. V.150. N1. P.75-78. DOI: 10.1007/s10517-010-1073-2 WOS Scopus РИНЦ OpenAlex
Original:
Кирилюк И.А.
, Каледин В.И.
, Попова Н.А.
, Николин В.П.
, Васильева Е.Д.
, Григорьев И.А.
, Лушникова Е.Л.
, Непомнящих Г.И.
Нитроксильный антиоксидант tppa-tempo повышает эффективность противоопухолевой терапии на модели перевиваемой лимфосаркомы мышей
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2010. Т.150. №7. С.85-89. РИНЦ
Нитроксильный антиоксидант tppa-tempo повышает эффективность противоопухолевой терапии на модели перевиваемой лимфосаркомы мышей
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2010. Т.150. №7. С.85-89. РИНЦ
Dates:
| Published online: | Nov 25, 2010 |
| Published print: | Dec 1, 2010 |
Identifiers:
| Web of science: | WOS:000284906200022 |
| Scopus: | 2-s2.0-79951637509 |
| Elibrary: | 16635508 |
| OpenAlex: | W2058772137 |