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Design of liposome-based pH sensitive nanoSPIN probes: nano-sized particles with incorporated nitroxides Научная публикация

Журнал Analyst
ISSN: 0003-2654 , E-ISSN: 1364-5528
Вых. Данные Год: 2009, Том: 134, Номер: 5, Страницы: 904-910 Страниц : DOI: 10.1039/b818184e
Авторы Woldman Yakov Y. 1,3 , Semenov Sergey V. 1,2 , Bobko Andrey A. 1 , Kirilyuk Igor A. 4 , Polienko Julya F. 4 , Voinov Maxim A. 5 , Bagryanskaya Elena G. 2 , Khramtsov Valery V. 1
Организации
1 (Данные Web of science) Ohio State Univ, Med Ctr, Columbus, OH 43210 USA
2 (Данные Web of science) Int Tomog Ctr SB RAS, Novosibirsk 630090, Russia
3 (Данные Web of science) Valdosta State Univ, Valdosta, GA 31698 USA
4 (Данные Web of science) Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
5 (Данные Web of science) N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

Реферат: Liposome-based nanoSized Particles with Incorporated Nitroxides, or nanoSPINs, were designed for EPR applications as pH probes in biological systems. Phospholipid membrane of the liposomes with incorporated gramicidin A showed selective permeability to a small analyte, H+, while protecting entrapped sensing nitroxide from biological reductants. An application of the pH-sensitive nanoSPIN in an ischemia model in rat heart homogenate allows for monitoring ischemia-induced acidosis while protecting encapsulated nitroxide against bioreduction.
Библиографическая ссылка: Woldman Y.Y. , Semenov S.V. , Bobko A.A. , Kirilyuk I.A. , Polienko J.F. , Voinov M.A. , Bagryanskaya E.G. , Khramtsov V.V.
Design of liposome-based pH sensitive nanoSPIN probes: nano-sized particles with incorporated nitroxides
Analyst. 2009. V.134. N5. P.904-910. DOI: 10.1039/b818184e WOS Scopus РИНЦ OpenAlex
Файлы: Полный текст от издателя
Идентификаторы БД:
Web of science: WOS:000265355600014
Scopus: 2-s2.0-65349120023
РИНЦ: 13613318
OpenAlex: W2082153374
Цитирование в БД:
БД Цитирований
Web of science 27
Scopus 27
РИНЦ 28
OpenAlex 27
Альметрики: