Ultrafine organic aerosol particles inhaled by mice at low doses remain in lungs more than half a year

Ultrafine organic aerosol particles inhaled by mice at low doses remain in lungs more than half a year Full article

Journal

Journal of Labelled Compounds and Radiopharmaceuticals
ISSN: 0362-4803 , E-ISSN: 1099-1344

Output data

Year: 2019, Volume: 62, Number: 11, Pages: 785-793 Pages count : 9 DOI: 10.1002/jlcr.378810.1002/jlcr.3788

Tags

accelerator mass spectrometry; low-dose inhalation; mice; organic aerosols; polystyrene beads; radiocarbon

Authors

Parkhomchuk Ekaterina V. ^1,2,3 , Prokopyeva Elena A. ¹ , Gulevich Dayana G. ¹ , Taratayko Anrey I. ^1,4 , Baklanov Anatoly M. ⁵ , Kalinkin Peter N. ^1,2 , Rastigeev Sergey A. ^1,6 , Kuleshov Dmitry V. ¹ , Sashkina Kseniya A. ^1,2 , Parkhomchuk Vasiliy V. ^1,6

Affiliations

1	(Данные Web of science) Novosibirsk State Univ, Lab Radiocarbon Methods Anal, Novosibirsk, Russia
2	(Данные Web of science) SB RAS, Boreskov Inst Catalysis, 5 Lavrentieva St, Novosibirsk 630090, Russia
3	(Данные Web of science) Fed Res Ctr Fundamental & Translat Med, Novosibirsk, Russia
4	(Данные Web of science) SB RAS, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk, Russia
5	(Данные Web of science) SB RAS, Voevodsky Inst Chem Kinet & Combust, Novosibirsk, Russia
6	(Данные Web of science) SB RAS, Budker Inst Nucl Phys, Novosibirsk, Russia

Experimental results of the second series of experiments on the penetration of monodisperse polymeric particles, inhaled at low dose by mice, to different organs using direct way of particle registration, based on the ultra-sensitive accelerator mass spectrometer (AMS), are presented. Polystyrene (PS) beads, composed of radiocarbon-labeled styrene, were produced for testing them as model organic aerosols. Mice inhaled C-14-PS aerosol of 3 center dot 10(5) ultrafine particles per 1 cm(3) for 30 minutes every day during 5 days. Long-term investigation showed that PS ultrafine particles have been effectively accumulated in lungs with the maximum content in the fifth day of postexposure, and have also appeared in liver on the fifth day of exposure and in the brain on the 30th day of experiments. No particles have been detected in kidneys, spleen, and excrements. Thirty-five millions of particles remained in the lungs after half a year of postexposure showing extremely slow removal of such particles from the organ.

Parkhomchuk E.V. , Prokopyeva E.A. , Gulevich D.G. , Taratayko A.I. , Baklanov A.M. , Kalinkin P.N. , Rastigeev S.A. , Kuleshov D.V. , Sashkina K.A. , Parkhomchuk V.V.
Ultrafine organic aerosol particles inhaled by mice at low doses remain in lungs more than half a year
Journal of Labelled Compounds and Radiopharmaceuticals. 2019. V.62. N11. P.785-793. DOI: 10.1002/jlcr.378810.1002/jlcr.3788 WOS РИНЦ

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