Brominated and iodinated thiofluoresceins Full article
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Russian Journal of Organic Chemistry
ISSN: 1070-4280 , E-ISSN: 1608-3393 |
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| Output data | Year: 2008, Volume: 44, Number: 10, Pages: 1538-1542 Pages count : 5 DOI: 10.1134/S1070428008100242 | ||
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Abstract:
Conditions were found for the synthesis of mono-, di-, tri-, and tetrabromo- and -iodo-substituted thiofluoresceins. Iodination and bromination of thiofluorescein with molecular iodine and bromine in 1 N aqueous sodium hydroxide gave mixtures of the corresponding 2,4,5,7-tetra- and 2,4,5-trihalo derivatives in 71/14 (Y = I) and 73/13% yield (Y = Br), respectively. In the reactions of thiofluorescein with bromine in acetic acid and with iodine in methanol at a substrate-to-halogen ratio of 1 : 2, 4,5-dibromo- and 4,5-diiodothiofluoresceins were isolated in 56 and 67% yield. Analogous reactions with equimolar amounts of the reactants produced 59% of 4-bromothiofluorescein and 51% of 4-iodothiofluorescein.
Cite:
Russkikh V.V.
, Vasil'ev E.V.
, Shelkovnikov V.V.
Brominated and iodinated thiofluoresceins
Russian Journal of Organic Chemistry. 2008. V.44. N10. P.1538-1542. DOI: 10.1134/S1070428008100242 WOS Scopus РИНЦ OpenAlex
Brominated and iodinated thiofluoresceins
Russian Journal of Organic Chemistry. 2008. V.44. N10. P.1538-1542. DOI: 10.1134/S1070428008100242 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Oct 1, 2008 |
| Published online: | Nov 9, 2008 |
Identifiers:
| Web of science: | WOS:000260783600024 |
| Scopus: | 2-s2.0-55949097676 |
| Elibrary: | 13591764 |
| OpenAlex: | W1999302718 |