Cardiomyocyte count in rat myocardium under the effect of antitumor agents cyclophosphamide and triterpenoids Научная публикация
| Журнал |
Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888 |
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| Вых. Данные | Год: 2007, Том: 144, Номер: 3, Страницы: 355-361 Страниц : 7 DOI: 10.1007/s10517-007-0332-3 | ||||
| Ключевые слова | cardiotoxicity; cyclophosphamide; betulonic acid and its amide; cardiomyocyte count | ||||
| Авторы |
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| Организации |
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Реферат:
Structural reorganization of the myocardium in response to antitumor agents (cyclophosphamide, betulonic acid and its amide) was studied. Cardiotoxic effects of these chemicals manifested in cardiomyocyte contracture and lytic injuries and by significant hemodynamic disorders. The most pronounced lytic and necrobiotic changes in cardiomyocytes were detected after injection of cyclophosphamide followed by betulonic amide; this led to a more pronounced decrease in heart weight as a result of a decrease in total cardiomyocyte count. Antitumor drugs differently changed the ratio of mono-to binuclear cardiomyocytes, which differ by their regeneratory and compensatory adaptive potential.
Библиографическая ссылка:
Lushnikova E.L.
, Tolstikova T.G.
, Nepomnyashchikh L.M.
, Klinnikova M.G.
, Molodykh O.P.
, Sviridov E.A.
, Sorokina I.V.
, Zhukova N.A.
Cardiomyocyte count in rat myocardium under the effect of antitumor agents cyclophosphamide and triterpenoids
Bulletin of Experimental Biology and Medicine. 2007. V.144. N3. P.355-361. DOI: 10.1007/s10517-007-0332-3 WOS Scopus РИНЦ OpenAlex
Cardiomyocyte count in rat myocardium under the effect of antitumor agents cyclophosphamide and triterpenoids
Bulletin of Experimental Biology and Medicine. 2007. V.144. N3. P.355-361. DOI: 10.1007/s10517-007-0332-3 WOS Scopus РИНЦ OpenAlex
Даты:
| Опубликована в печати: | 1 сент. 2007 г. |
Идентификаторы БД:
| Web of science: | WOS:000251865400025 |
| Scopus: | 2-s2.0-37749046078 |
| РИНЦ: | 13548080 |
| OpenAlex: | W1972513892 |