Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable Lewis carcinoma Full article
| Journal |
Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888 |
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| Output data | Year: 2006, Volume: 142, Number: 1, Pages: 69-72 Pages count : 4 DOI: 10.1007/s10517-006-0294-x | ||||
| Tags | transplantable tumor; antitumor effect; antimetastatic effect; betulonic acid; 2-and 3-[3-oxo-20(29)-lupen-28-oilamino]-propionic acid | ||||
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Abstract:
We studied the effects of four synthetic amides of betulonic acid containing amino acid fragments (d,l-alpha-alanine, beta-alanine, and their methyl esters) on the rate of growth and metastatic dissemination of transplantable Lewis lung carcinoma in C57Bl/6 mice. The test compounds were administered intragastrically in a single dose of 500 mg/kg. 3[-oxo-20(29)-lupen-28-oilamino]-propionic acid suppressed primary tumor growth (by 26%) and decreased the number of lung metastases (by more than 2 times). Antitumor and antimetastatic activity of triterpenoids decreased after methylation of the amino acid fragment in betulonic acid.
Cite:
Sorokina I.V.
, Tolstikova T.G.
, Zhukova N.A.
, Petrenko N.I.
, Uzenkova N.V.
, Shul'ts E.E.
, Popova N.A.
Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable Lewis carcinoma
Bulletin of Experimental Biology and Medicine. 2006. V.142. N1. P.69-72. DOI: 10.1007/s10517-006-0294-x WOS Scopus РИНЦ OpenAlex
Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable Lewis carcinoma
Bulletin of Experimental Biology and Medicine. 2006. V.142. N1. P.69-72. DOI: 10.1007/s10517-006-0294-x WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Jul 1, 2006 |
Identifiers:
| Web of science: | WOS:000242633100020 |
| Scopus: | 2-s2.0-33750470388 |
| Elibrary: | 13506978 |
| OpenAlex: | W1987527513 |