Effect of betulonic acid and its derivative [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid on liver structure in mice with RLS lymphoma Full article
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Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888 |
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| Output data | Year: 2005, Volume: 140, Number: 3, Pages: 361-364 Pages count : 4 DOI: 10.1007/s10517-005-0490-0 | ||||||
| Tags | polychemotherapy; liver; hepatoprotective effect; betulonic acid; [3-oxo20(29)-lttpene-28-oyl]-3-aininopropionic acid | ||||||
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Abstract:
Morphological study of the effects of semisynthetic derivatives of betulin (betulonic acid and [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid) on the liver of CBA/Lac mice with transplanted RLS lymphoma was studied in the control and after cytostatic polychemotherapy. The number of small focal necroses decreased, while the counts of hepatocytes in a state of slight hyaline droplet degeneration increased. Morphometry of the main elements of liver parenchyma showed that alanine amide derivative of betulonic acid decreases the severity of necrotic and degenerative changes in the liver parenchyma, induced by cytostatic polychemotherapy. Betulonic acid exhibited no appreciable hepatoprotective effect under these conditions.
Cite:
Zhukova N.A.
, Semenov D.E.
, Sorokina I.V.
, Tolstikova T.G.
, Pozdnyakova S.V.
, Grek O.R.
Effect of betulonic acid and its derivative [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid on liver structure in mice with RLS lymphoma
Bulletin of Experimental Biology and Medicine. 2005. V.140. N3. P.361-364. DOI: 10.1007/s10517-005-0490-0 WOS Scopus РИНЦ OpenAlex
Effect of betulonic acid and its derivative [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid on liver structure in mice with RLS lymphoma
Bulletin of Experimental Biology and Medicine. 2005. V.140. N3. P.361-364. DOI: 10.1007/s10517-005-0490-0 WOS Scopus РИНЦ OpenAlex
Original:
Жукова Н.А.
, Семенов Д.Е.
, Сорокина И.В.
, Толстикова Т.Г.
, Позднякова С.В.
, Грек О.Р.
Влияние бетулоновой кислоты и ее производного [3-оксо-20(29)-лупен-28-оил]-3-аминопропионовой кислоты на структуру печени мышей с лимфомой RLS 348
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2005. Т.140. №9. С.348-351. РИНЦ
Влияние бетулоновой кислоты и ее производного [3-оксо-20(29)-лупен-28-оил]-3-аминопропионовой кислоты на структуру печени мышей с лимфомой RLS 348
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2005. Т.140. №9. С.348-351. РИНЦ
Dates:
| Published print: | Sep 1, 2005 |
Identifiers:
| Web of science: | WOS:000234409200029 |
| Scopus: | 2-s2.0-28844442881 |
| Elibrary: | 13483489 |
| OpenAlex: | W2041757454 |