Absolute configuration of stizolicin and synthesis and biological activity of its amino derivatives

Absolute configuration of stizolicin and synthesis and biological activity of its amino derivatives Full article

Journal

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Output data

Year: 2005, Volume: 41, Number: 5, Pages: 561-564 Pages count : 4 DOI: 10.1007/s10600-005-0206-8

Tags

Stizolophus balsamita; germacranolides; PMR; x-ray structure analysis; antimicrobial activity

Authors

Suleimenov EM , Raidugin VA , Gatilov YV , Bagryanskaya IY , Seidakhmetova R , Aksartov RM , Adekenov SM

Affiliations

1	(Данные Web of science) Minist Educ & Sci Republ Kazakhstan, Inst Phytochem, Karaganda 470032, Kazakhstan
2	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Div, Novosibirsk 630090, Russia

Reaction of the germacranolide stizolicin with secondary amines formed normal products of a Michael reaction at the exomethylene group and simultaneously led to solvolysis with cleavage of the acyl group. The structures of the molecules were established by XSA. Use of the HI salt of one of the resulting amines enabled the proof of its absolute configuration and that of the starting stizolicin, which had previously only been proposed. Stizolicin and the synthesized compounds were screened for antimicrobial and antitrichomonal activity.

Suleimenov E. , Raidugin V. , Gatilov Y. , Bagryanskaya I. , Seidakhmetova R. , Aksartov R. , Adekenov S.
Absolute configuration of stizolicin and synthesis and biological activity of its amino derivatives
Chemistry of Natural Compounds. 2005. V.41. N5. P.561-564. DOI: 10.1007/s10600-005-0206-8 WOS Scopus РИНЦ OpenAlex

Published print:

Sep 1, 2005

Web of science:	WOS:000234968300018
Scopus:	2-s2.0-30544454933
Elibrary:	13499827
OpenAlex:	W1990841180

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