A prototype prophylactic anti-influenza preparation in aerosol form on the basis of Abies sibirica polyprenols

A prototype prophylactic anti-influenza preparation in aerosol form on the basis of Abies sibirica polyprenols Научная публикация

Журнал

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung
ISSN: 0894-2684

Вых. Данные

Год: 2005, Том: 18, Номер: 1, Страницы: 55-62 Страниц : 8 DOI: 10.1089/jam.2005.18.55

Авторы

Safatov AS ¹ , Boldyrev A ¹ , Bulychev LE ¹ , Buryak GA ¹ , Kukina TP ² , Poryvaev VD ¹ , P'Yankov OV ¹ , Raldugin VA ² , Ryzhikov AB ¹ , Sergeev AN ¹ , Shishkina LN ¹ , Tolstikov GA ² , Zhukov VA ¹

Организации

1	(Данные Web of science) State Res Ctr Virol & Biotechnol Vector, Koltsov 630559, Novosibirsk, Russia
2	(Данные Web of science) Russian Acad Sci, Novosibirsk Organ Chem Inst, Siberian Branch, Novosibirsk, Russia

This research investigates a promising antiviral compound based on polyprenols from Siberian silver fir (Abies sibirica). The physico-chemical characteristics of a preparation developed in aerosol form and an estimation of its protective efficacy against aerosol challenge of laboratory animals are presented. It is shown that (1) by using a simple ultrasonic disperser one can obtain aerosol of three formulations studied with about 70% of its mass accumulated in the size range below 1.8 mu m; (2) 40-100% of aerosol particles contain preparation for different formulations; (3) after delivering under specified schedules, the preparations as developed can protect up to 100% of mice against 5 LD50 of influenza A/Aichi/2/68 (H3N2) virus aerosol infection. Animals inhaled twice the preparation doses (which were 100 times lower than injection ones of the same efficacy) and did not exceed 10 mu g/mouse. It was shown that the mode of action of this immunomodulating preparation was nonspecific stimulation of immune cells' various activities.

Safatov A. , Boldyrev A. , Bulychev L. , Buryak G. , Kukina T. , Poryvaev V. , P'Yankov O. , Raldugin V. , Ryzhikov A. , Sergeev A. , Shishkina L. , Tolstikov G. , Zhukov V.
A prototype prophylactic anti-influenza preparation in aerosol form on the basis of Abies sibirica polyprenols
Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung. 2005. V.18. N1. P.55-62. DOI: 10.1089/jam.2005.18.55 WOS Scopus РИНЦ OpenAlex

Опубликована в печати:

1 мар. 2005 г.

Web of science:	WOS:000227628900005
Scopus:	2-s2.0-20044378279
РИНЦ:	13482722
OpenAlex:	W2049236215

БД	Цитирований
Web of science	8
Scopus	16
РИНЦ	19
OpenAlex	14