Synthesis of novel derivatives of 2-(azolylimino)thiazoline

Synthesis of novel derivatives of 2-(azolylimino)thiazoline Full article

Journal

Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171

Output data

Year: 2004, Volume: 53, Number: 10, Pages: 2293-2302 Pages count : 10 DOI: 10.1007/s11172-005-0116-8

Tags

haloketone; alkylation; 2-imidazolylimino-Delta(4)-thiazolines; imidazo[5,1-c]pyrazin-7-ones; imidazolylthiourea; purine derivatives; alkyl halides; (N-alkylimidazolyl)isothioureas

Authors

Eltsov O.S. ¹ , Mokrushin V.S. ¹ , Tkachev A.V. ²

Affiliations

1	(Данные Web of science) Ural State Tech Univ, Ekaterinburg 620002, Russia
2	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Div, Novosibirsk 630090, Russia

Successive alkylation of 5-(3-phenylthioureido)-3H-imidazole-4-carboxamides with alkyl halides and chloroacetone gave (N-oxopropylimidazolyl)isothioureas, which were easily converted into derivatives of purine and imidazopyrazinone. In the case of ethyl 5-(3-phenylthioureido)-3H-imidazole-4-carboxylate, primary alkylation occurs at the N atom of the imidazole ring. Reactions of 5-(3-phenylthioureido)-3H-imidazole-4-carboxamides with halo-ketones afforded a number of 4-hydroxy-2-imidazolyliminothiazolidines and 2-imidazolylimino-Delta(4)-thiazolines.

Eltsov O.S. , Mokrushin V.S. , Tkachev A.V.
Synthesis of novel derivatives of 2-(azolylimino)thiazoline
Russian Chemical Bulletin. 2004. V.53. N10. P.2293-2302. DOI: 10.1007/s11172-005-0116-8 WOS Scopus РИНЦ OpenAlex

Published print:

Oct 1, 2004

Web of science:	WOS:000227891300038
Scopus:	2-s2.0-21644438588
Elibrary:	13469642
OpenAlex:	W2950387796

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Web of science	4
Scopus	3
Elibrary	3
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