Synthesis of quinoxalines fused with triterpenes, ursolic acid and betulin derivatives

Synthesis of quinoxalines fused with triterpenes, ursolic acid and betulin derivatives Научная публикация

Журнал

Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171

Вых. Данные

Год: 2001, Том: 50, Номер: 2, Страницы: 304-310 Страниц : 7 DOI: 10.1023/A:1009598805986

Ключевые слова

triterpenoids; ursolic acid; betulin; allobetulin; quinoxaline; pyrazine; H-1 and C-13 NMR spectroscopy; oxidation; molecular oxygen; alpha-diketones; o-phenylenediamine

Авторы

Korovin A.V. ¹ , Tkachev A.V. ²

Организации

1	Department of Natural Sciences, Novosibirsk State University, 3a ul. Instituskaya, 630090, Novosibirsk, Russian Federation
2	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrent"eva, 630090, Novosibirsk, Russian Federation

Oxidation of triterpenoids methyl ursonate, acetylbetulone, and allobetulone with atmospheric oxygen in the presence of (BuOK)-O-t in (BuOH)-O-t afforded the corresponding 2,3-diketo derivatives in 90-97% yields. These derivatives exist predominantly as tautomers containing the enolized keto group at the C(2) atom. Their reactions with o-phenylenediamine gave rise to the corresponding quinoxalines in 85-95% yields.

Korovin A.V. , Tkachev A.V.
Synthesis of quinoxalines fused with triterpenes, ursolic acid and betulin derivatives
Russian Chemical Bulletin. 2001. V.50. N2. P.304-310. DOI: 10.1023/A:1009598805986 WOS Scopus РИНЦ OpenAlex

Web of science:	WOS:000173636600026
Scopus:	2-s2.0-0035536487
РИНЦ:	13365391
OpenAlex:	W2997954291

БД	Цитирований
Web of science	25
Scopus	24
РИНЦ	37
OpenAlex	23