Michael addition of ethyl acetoacetate to alpha,beta-unsaturated oximes in the presence of FeCl3: a novel synthetic route to substituted nicotinic acid derivatives

Michael addition of ethyl acetoacetate to alpha,beta-unsaturated oximes in the presence of FeCl3: a novel synthetic route to substituted nicotinic acid derivatives Full article

Journal

Tetrahedron Letters
ISSN: 0040-4039

Output data

Year: 2000, Volume: 41, Number: 41, Pages: 8011-8013 Pages count : DOI: 10.1016/S0040-4039(00)01391-5

Tags

Michael addition; iron(III) chloride hexahydrate; unsaturated oxime; nicotinic acid

Authors

Chibiryaev AM , De Kimpe N , Tkachev AV

Affiliations

1	(Данные Web of science) Novosibirsk Organ Chem Inst, Novosibirsk 630090, Russia
2	(Данные Web of science) Novosibirsk State Univ, Dept Nat Sci, Novosibirsk 630090, Russia
3	(Данные Web of science) State Univ Ghent, Fac Agr & Appl Biol Sci, Dept Organ Chem, B-9000 Ghent, Belgium

The FeCl3-catalyzed reaction of alpha,beta-unsaturated oximes with ethyl acetoacetate resulted in Michael addition followed by ring closure to produce substituted nicotinic acid derivatives in a very efficient way. (C) 2000 Elsevier Science Ltd. All rights reserved.

Chibiryaev A. , De Kimpe N. , Tkachev A.
Michael addition of ethyl acetoacetate to alpha,beta-unsaturated oximes in the presence of FeCl3: a novel synthetic route to substituted nicotinic acid derivatives
Tetrahedron Letters. 2000. V.41. N41. P.8011-8013. DOI: 10.1016/S0040-4039(00)01391-5 WOS Scopus OpenAlex

Published print:

Oct 1, 2000

Web of science:	WOS:000089809800049
Scopus:	2-s2.0-0034619162
OpenAlex:	W2033125110

DB	Citing
Web of science	34
Scopus	37
OpenAlex	32