Spin trapping of O-, C-, and S-centered radicals and peroxynitrite by 2H-imidazole-1-oxides Full article
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Biochemical and Biophysical Research Communications
ISSN: 0006-291X , E-ISSN: 1090-2104 |
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| Output data | Year: 1996, Volume: 218, Number: 2, Pages: 616-622 Pages count : 7 DOI: 10.1006/bbrc.1996.0109 | ||||
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Abstract:
Spin trapping with 2H-imidazole-1-oxides (2,2,4-trimethyl-2H-imidazole-1-oxide (TMIO); 4-carboxy-2,2-dimethyl-2H-imidazole- 1-oxide, potassium salt (CDMIO); 2,2-dimethyl-4-phenyl-2H-imidazole-1-oxide (DMPIO)) was studied. It was found that these compounds form spin adducts with different short lived free radicals, such as OH, CH3, CH2OH, CH3(CH)OH, C(CH3)(3)O, HOCH2CH2S, glutathionyl and cysteinyl radicals. 2H-imidazole-1-oxides did not trap superoxide radical. Therefore, the detection of OH and thiol radicals is nor complicated by the presence of superoxide radical. It was shown that 2H-imidazole-1 -oxides are effective scavengers of peroxynitrite forming the same spin adducts as with OH-radicals. Thus, TMIO, CDMIO and DMPIO can be used for spin trapping studies in chemical and biological systems. (C) 1996 Academic Press, Inc.
Cite:
Dikalov S.
, Kirilyuk I.
, Grigorev I.
Spin trapping of O-, C-, and S-centered radicals and peroxynitrite by 2H-imidazole-1-oxides
Biochemical and Biophysical Research Communications. 1996. V.218. N2. P.616-622. DOI: 10.1006/bbrc.1996.0109 WOS Scopus OpenAlex
Spin trapping of O-, C-, and S-centered radicals and peroxynitrite by 2H-imidazole-1-oxides
Biochemical and Biophysical Research Communications. 1996. V.218. N2. P.616-622. DOI: 10.1006/bbrc.1996.0109 WOS Scopus OpenAlex
Dates:
| Published print: | Jan 1, 1996 |
Identifiers:
| Web of science: | WOS:A1996TQ56500035 |
| Scopus: | 2-s2.0-0030034340 |
| OpenAlex: | W2024643024 |