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The effect of 3,7-diazabicyclo[3.3.1]nonanes containing monoterpenoid moieties on the physical activity of mice Full article

Journal Journal of Research in Pharmacy
ISSN: 2630-6344
Output data Year: 2020, Volume: 24, Number: 2, Pages: 196-204 Pages count : 9 DOI: 10.35333/jrp.2020.136
Tags Actoprotectors; treadmill; bromantane; monoterpenoids; bispidine
Authors Kotlyarova Anastasiya A. 3 , Ponomarev Konstantin Yu 1 , Morozova Ekaterina A. 1 , Korchagina Dina, V 2 , Suslov Evgeniy, V 1 , Pavlova Alla, V 1 , Tolstikova Tatyana G. 1 , Volcho Konstantin P. 1 , Salakhutdinov Nariman F. 1
Affiliations
1 (Данные Web of science) Russian Acad Sci, Dept Med Chem, Novosibirsk Inst Organ Chem, Siberian Branch, Lavrentjev Av 9, Novosibirsk 630090, Russia
2 (Данные Web of science) Russian Acad Sci, Dept Phys Organ Chem, Novosibirsk Inst Organ Chem, Siberian Branch, Lavrentjev Av 9, Novosibirsk 630090, Russia
3 (Данные Web of science) Russian Acad Sci, Dept Expt Pharmacol, Res Inst Clin & Expt Lymphol, Inst Cytol & Genet,Siberian Branch, Acad Timakova Str 2, Novosibirsk 630060, Russia

Abstract: The aim of this work is to study the effect of agents combining fragments of monoterpenoids and 3,7-diazabicyclo[3.3.1]nonane (bispidine) on the performance of mice. Physical endurance was studied using two tests: exhaustive swimming with a load of 7% of body weight (after single dosing) and exhaustive treadmill running (after single dosing and a 7-day administration). It has been shown for the first time that derivatives of monoterpenoids with 3,7-diazabicyclo[3.3.1]nonane moiety containing methyl substituents at positions 1 and 5 have a stimulatory effect on the performance of mice, which exceeds the effect of the reference drug bromantane after single dosing. Compound K1-458, which contains (-)-myrtenal residues linked to a bispidine fragment via amino groups, is the most effective in increasing the duration of running and swimming at a dose of 100 mg/kg after single intragastric administration. It has been also established that the LD50 for these compounds exceeds 1,000 mg/kg.
Cite: Kotlyarova A.A. , Ponomarev K.Y. , Morozova E.A. , Korchagina D.V. , Suslov E.V. , Pavlova A.V. , Tolstikova T.G. , Volcho K.P. , Salakhutdinov N.F.
The effect of 3,7-diazabicyclo[3.3.1]nonanes containing monoterpenoid moieties on the physical activity of mice
Journal of Research in Pharmacy. 2020. V.24. N2. P.196-204. DOI: 10.35333/jrp.2020.136 WOS Scopus OpenAlex
Files: Full text from publisher
Dates:
Published print: Mar 12, 2020
Identifiers:
Web of science: WOS:000520855700003
Scopus: 2-s2.0-85085118551
OpenAlex: W3012226578
Citing:
DB Citing
Web of science 5
Scopus 5
OpenAlex 6
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