Synthesis of polyfluorinated o-hydroxyacetophenones - convenient precursors of 3-benzylidene-2-phenylchroman-4-ones Научная публикация
| Журнал |
Journal of Fluorine Chemistry
ISSN: 0022-1139 |
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| Вых. Данные | Год: 2020, Том: 229, Номер статьи : UNSP 109435, Страниц : DOI: 10.1016/j.jfluchem.2019.109435 | ||||||
| Ключевые слова | Fluorinated o-iodophenols; o-hydroxyacetophenones; Palladium catalysis; Sonogashira coupling; Hydration reaction; Aldol reaction | ||||||
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Реферат:
A simple and efficient approach to the synthesis of fluorinated o-hydroxyacetophenones in good to excellent yields is reported. We demonstrated a convenient method for replacing the iodine atom in o-iodophenols with MeC(O)-group through the introduction and subsequent hydrolysis of TIPS-CC-moiety by of p-toluenesulfonic acid monohydrate. The resulting compounds may serve as precursors for the synthesis of polyfluorinated 3-benzylidene-2-phenylchroman-4-one derivatives that are of interest as objects for the evaluation of their pharmacological properties.
Библиографическая ссылка:
Politanskaya L.
, Tretyakov E.
, Xi C.
Synthesis of polyfluorinated o-hydroxyacetophenones - convenient precursors of 3-benzylidene-2-phenylchroman-4-ones
Journal of Fluorine Chemistry. 2020. V.229. UNSP 109435 . DOI: 10.1016/j.jfluchem.2019.109435 WOS Scopus РИНЦ OpenAlex
Synthesis of polyfluorinated o-hydroxyacetophenones - convenient precursors of 3-benzylidene-2-phenylchroman-4-ones
Journal of Fluorine Chemistry. 2020. V.229. UNSP 109435 . DOI: 10.1016/j.jfluchem.2019.109435 WOS Scopus РИНЦ OpenAlex
Даты:
| Опубликована в печати: | 1 янв. 2020 г. |
Идентификаторы БД:
| Web of science: | WOS:000509631900005 |
| Scopus: | 2-s2.0-85076198965 |
| РИНЦ: | 43216378 |
| OpenAlex: | W2990999439 |