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In Vivo Extracellular pH Mapping of Tumors Using Electron Paramagnetic Resonance Научная публикация

Журнал Analytical Chemistry
ISSN: 0003-2700 , E-ISSN: 1520-6882
Вых. Данные Год: 2018, Том: 90, Номер: 23, Страницы: 13938-13945 Страниц : 8 DOI: 10.1021/acs.analchem.8b03328
Авторы Komarov Denis A. 1,7 , Ichikawa Yuki 1 , Yamamoto Kumiko 2 , Stewart Neil J. 1 , Matsumoto Shingo 1 , Yasui Hironobu 3 , Kirilyuk Igor A. 4 , Khramtsov Valery V. 5,6 , Inanami Osamu 2 , Hirata Hiroshi 1
Организации
1 (Данные Web of science) Hokkaido Univ, Div Bioengn & Bioinformat, Grad Sch Informat Sci & Technol, Kita Ku, North 14,West 9, Sapporo, Hokkaido 0600814, Japan
2 (Данные Web of science) Hokkaido Univ, Lab Radiat Biol, Grad Sch Vet Med, Kita Ku, North 18,West 9, Sapporo, Hokkaido 0600818, Japan
3 (Данные Web of science) Hokkaido Univ, Cent Inst Isotope Sci, Kita Ku, North 15,West 7, Sapporo, Hokkaido 0600815, Japan
4 (Данные Web of science) NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Ac Lavrentieva Ave, Novosibirsk 630090, Russia
5 (Данные Web of science) West Virginia Univ, Robert C Byrd Hlth Sci Ctr, Dept Biochem, 1 Med Ctr Dr, Morgantown, WV 26506 USA
6 (Данные Web of science) West Virginia Univ, Robert C Byrd Hlth Sci Ctr, In Vivo Multifunct Magnet Resonance Ctr, 1 Med Ctr Dr, Morgantown, WV 26506 USA
7 (Данные Web of science) Ohio State Univ, Davis Heart & Lung Res Inst, Columbus, OH 43210 USA

Реферат: An electron paramagnetic resonance (EPR)based method for noninvasive three-dimensional extracellular pH mapping was developed using a pH-sensitive nitroxyl radical as an exogenous paramagnetic probe. Fast projection scanning with a constant magnetic field sweep enabled the acquisition of four-dimensional (3D spatial +1D spectral) EPR images within 7.5 min. Three-dimensional maps of pH were reconstructed by processing the pH-dependent spectral information on the images. To demonstrate the proposed method of pH mapping, the progress of extracellular acidosis in tumor-bearing mouse legs was studied. Furthermore, extracellular pH mapping was used to visualize the spatial distribution of acidification in different tumor xenograft mouse models of human-derived pancreatic ductal adenocarcinoma cells. The proposed EPR-based pH mapping method enabled quantitative visualization of regional changes in extracellular pH associated with altered tumor metabolism.
Библиографическая ссылка: Komarov D.A. , Ichikawa Y. , Yamamoto K. , Stewart N.J. , Matsumoto S. , Yasui H. , Kirilyuk I.A. , Khramtsov V.V. , Inanami O. , Hirata H.
In Vivo Extracellular pH Mapping of Tumors Using Electron Paramagnetic Resonance
Analytical Chemistry. 2018. V.90. N23. P.13938-13945. DOI: 10.1021/acs.analchem.8b03328 WOS Scopus РИНЦ OpenAlex
Файлы: Полный текст от издателя
Даты:
Опубликована online: 29 окт. 2018 г.
Опубликована в печати: 4 дек. 2018 г.
Идентификаторы БД:
Web of science: WOS:000452693600018
Scopus: 2-s2.0-85058093141
РИНЦ: 38644745
OpenAlex: W2898624162
Цитирование в БД:
БД Цитирований
Web of science 29
Scopus 32
РИНЦ 30
OpenAlex 34
Альметрики: