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Synthesis of hybrid molecules containing pyrimidine and diterpene alkaloid lappaconitine fragments Full article

Journal Chemistry of Heterocyclic Compounds
ISSN: 0009-3122 , E-ISSN: 1573-8353
Output data Year: 2018, Volume: 54, Number: 12, Pages: 1131-1138 Pages count : 8 DOI: 10.1007/s10593-019-02404-w
Tags alkaloids; alkynes; amidines; pyrimidines; cross coupling; one-pot synthesis
Authors Cheremnykh Kirill P. 1 , Savel'ev Viktor A. 1 , Shkurko Oleg P. 1 , Shults Elvira E. 1,2
Affiliations
1 (Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, 9 Akad Lavrentieva Ave, Novosibirsk 630090, Russia
2 (Данные Web of science) Novosibirsk State Univ, 1 Pirogova St, Novosibirsk 630090, Russia

Abstract: The cross coupling of 5'-ethynyllappaconitine with benzoic acid chlorides under the conditions of the Sonogashira reaction in benzene leads to the corresponding 5-alkynones. By condensation of the obtained 5'-alkynones with amidines, compounds with hybrid structure containing fragments of a diterpene alkaloid and pyrimidine were synthesized. The yields of the target compounds were 67-90%. The possibility of carrying out the cross coupling - condensation reaction as a one-pot synthesis is demonstrated.
Cite: Cheremnykh K.P. , Savel'ev V.A. , Shkurko O.P. , Shults E.E.
Synthesis of hybrid molecules containing pyrimidine and diterpene alkaloid lappaconitine fragments
Chemistry of Heterocyclic Compounds. 2018. V.54. N12. P.1131-1138. DOI: 10.1007/s10593-019-02404-w WOS Scopus РИНЦ OpenAlex
Dates:
Published print: Dec 1, 2018
Published online: Jan 18, 2019
Identifiers:
Web of science: WOS:000461553300008
Scopus: 2-s2.0-85060186594
Elibrary: 38667200
OpenAlex: W2909181259
Citing:
DB Citing
Web of science 6
Scopus 8
Elibrary 5
OpenAlex 9
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