Effect of Microwave Irradiation on Arabinogalactan and Its Interaction with Betulin Diacetate

Effect of Microwave Irradiation on Arabinogalactan and Its Interaction with Betulin Diacetate Full article

Journal

Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620

Output data

Year: 2018, Volume: 44, Number: 7, Pages: 870-875 Pages count : 6 DOI: 10.1134/S1068162018070075

Tags

arabinogalactan; betulin diacetate; microwave irradiation; complexation; solubility

Authors

Malyar Yu.N. ^1,2 , Mikhailenko M.A. ³ , Pankrushina N.A. ⁴ , Mikheev A.N. ⁵ , Kuznetsova S.A. ^1,2 , Shakhtshneider T.P. ^3,5

Affiliations

1	(Данные Web of science) RAS, SB, FRC,KSC, Inst Chem & Chem Technol, Krasnoyarsk 660036, Russia
2	(Данные Web of science) Siberian Fed Univ, Krasnoyarsk 660041, Russia
3	(Данные Web of science) RAS, SB, Inst Solid State Chem & Mechanochem, Novosibirsk 630128, Russia
4	(Данные Web of science) RAS, SB, Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
5	(Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia

Betulin diacetate (BDA) has a variety of biological activities, but poor solubility in water limits its application. The use of arabinogalactan (AG) as a complexing agent is a promising method for solving the problem of solubilization of drugs. In this study, effect of microwave (MW) irradiation on the properties of AG and BDA and their interaction in aqueous suspension with the formation of a water-soluble supramolecular complex was studied. It is shown that the microwave heating of AG under harsh conditions can lead to degradation of the biopolymer. The use of microwave heating could significantly reduce the complex preparation time compared to the conventional synthesis in a water bath. The preliminary mechanical treatment of the mixture of components, leading to the formation of mechanocomposites, inhibited the reaction between the components in the aqueous suspension under microwave irradiation. The IR spectroscopy method has shown that a supramolecular complex formed under microwave irradiation similar to that formed by conventional heating. The BDA-AG complex was isolated from a microwave heated solution as a thin film, which may be a promising material for pharmaceutical applications.

Malyar Y.N. , Mikhailenko M.A. , Pankrushina N.A. , Mikheev A.N. , Kuznetsova S.A. , Shakhtshneider T.P.
Effect of Microwave Irradiation on Arabinogalactan and Its Interaction with Betulin Diacetate
Russian Journal of Bioorganic Chemistry. 2018. V.44. N7. P.870-875. DOI: 10.1134/S1068162018070075 WOS Scopus РИНЦ OpenAlex

Published print:	Dec 1, 2018
Published online:	Feb 19, 2019

Web of science:	WOS:000459411400007
Scopus:	2-s2.0-85061801971
Elibrary:	38641439
OpenAlex:	W2916564944

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