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Synthesis and crystal structure of a meloxicam co-crystal with benzoic acid Научная публикация

Журнал Structural Chemistry
ISSN: 1040-0400 , E-ISSN: 1572-9001
Вых. Данные Год: 2018, Том: 29, Номер: 6, Страницы: 1867-1874 Страниц : DOI: 10.1007/s11224-018-1166-5
Ключевые слова Oxicam; Meloxicam; Solubility; Benzoic acid; Co-crystal; Co-former; Aromatic; Carboxylic acid
Авторы Tantardini Christian 1,2 , Arkipov Sergey G. 2,3 , Cherkashina Kseniya A. 2 , Kil'met'ev Alexander S. 2,4 , Boldyreva Elena V. 2,5
Организации
1 (Данные Web of science) SkolTech Skolkovo Inst Sci & Technol, Ul Nobelya 3, Moscow 121205, Russia
2 (Данные Web of science) Novosibirsk State Univ, Ul Pirogova 2, Novosibirsk 630090, Russia
3 (Данные Web of science) RAS, SB, Inst Solid State Chem & Mechanochem, Ul Kutateladze 18, Novosibirsk 630128, Russia
4 (Данные Web of science) RAS, SB, Novosibirsk Inst Organ Chem, Lavrentiev Ave 9, Novosibirsk 630090, Russia
5 (Данные Web of science) RAS, SB, Boreskov Inst Catalysis, Laverentiev Ave 5, Novosibirsk 630090, Russia

Реферат: Single crystals of a 1:1 co-crystal of meloxicam [4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-2H-1(6),2-benzothiazine-3-carboxamide], MXM, with benzoic acid, BZA, were crystalized from a THF solution. The same MXM-BZA co-crystal has been obtained as a fine powder by liquid-assisted co-grinding using as fluid additives solvents with different polarity: benzene, toluene, ortho-xylene, meta-xylene, para-xylene, THF, and water. The latter is especially eco-friendly and can be a good candidate for industrial production. The crystal structures of all the MXM co-crystals deposited in the most recent version of the Cambridge Database were compared, in order to correlate the non-covalent interactions in these structures with the ?onclusions from the theoretical analysis of solubility carried out by Cysewski (J. Mol. Model 24:112, 2018).
Библиографическая ссылка: Tantardini C. , Arkipov S.G. , Cherkashina K.A. , Kil'met'ev A.S. , Boldyreva E.V.
Synthesis and crystal structure of a meloxicam co-crystal with benzoic acid
Structural Chemistry. 2018. V.29. N6. P.1867-1874. DOI: 10.1007/s11224-018-1166-5 WOS Scopus РИНЦ OpenAlex
Даты:
Опубликована online: 25 июл. 2018 г.
Опубликована в печати: 1 дек. 2018 г.
Идентификаторы БД:
Web of science: WOS:000451767200027
Scopus: 2-s2.0-85050674493
РИНЦ: 41793303
OpenAlex: W2883590378
Цитирование в БД:
БД Цитирований
Web of science 10
Scopus 10
РИНЦ 10
OpenAlex 12
Альметрики: