Synthesis and Cytotoxicity of Conjugates of Betulinic Acid and F-Containing 2-Acylcycloalkane-1,3-Diones Full article
| Journal |
Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388 |
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| Output data | Year: 2018, Volume: 54, Number: 6, Pages: 1100-1105 Pages count : 6 DOI: 10.1007/s10600-018-2565-y | ||||
| Tags | betulinic acid; conjugates; 2-(fluoroacyl)cycloalkane-1; 3-diones; diamines; cytotoxicity | ||||
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Abstract:
Conjugates of betulinic acid with 2-(fluoroacyl)cycloalkane-1,3-dione motifs were synthesized by reacting 3-chloro-2-(fluoroacyl)-2-cycloalkene-1-ones with an equivalent amount of betulinic acid aminoalkylamide hydrochlorides in the presence of Et3N in CHCl3. Reduction of betulonic acid conjugates with 2-trifluoroacetylcyclopentane-1,3-dione by NaBH4 in THF produced betulinic acid derivatives containing 2-(1-hydroxy-2,2,2-trifluoroethyl)cyclopentane-1,3-dione. The cytotoxicity of the synthesized compounds was assessed against glioblastoma multiforme (U-87 MG) and breast cancer cell lines (MCF7).
Cite:
Khlebnikova T.S.
, Piven' Y.A.
, Lakhvich F.A.
, Frolova T.S.
, Sorokina I.V.
, Tolstikova T.G.
Synthesis and Cytotoxicity of Conjugates of Betulinic Acid and F-Containing 2-Acylcycloalkane-1,3-Diones
Chemistry of Natural Compounds. 2018. V.54. N6. P.1100-1105. DOI: 10.1007/s10600-018-2565-y WOS Scopus РИНЦ OpenAlex
Synthesis and Cytotoxicity of Conjugates of Betulinic Acid and F-Containing 2-Acylcycloalkane-1,3-Diones
Chemistry of Natural Compounds. 2018. V.54. N6. P.1100-1105. DOI: 10.1007/s10600-018-2565-y WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Nov 1, 2018 |
| Published online: | Nov 3, 2018 |
Identifiers:
| Web of science: | WOS:000449495400018 |
| Scopus: | 2-s2.0-85056109277 |
| Elibrary: | 43201651 |
| OpenAlex: | W2898736929 |