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SYNTHESIS AND INHIBITORY PROPERTIES OF IMINES CONTAINING MONOTERPENOID AND ADAMANTANE FRAGMENTS AGAINST DNA REPAIR ENZYME TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1) Full article

Journal Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388
Output data Year: 2018, Volume: 54, Number: 4, Pages: 672-676 Pages count : 5 DOI: 10.1007/s10600-018-2443-7
Tags adamantane; monoterpene; tyrosyl-DNA phosphodiesterase 1; DNA repair inhibitor; Schiff base
Authors Zakharenko A.L. 1 , Mozhaitsev E.S. 2 , Suslov E.V. 2 , Korchagina D.V. 2 , Volcho K.P. 2,3 , Salakhutdinov N.F. 2,3 , Lavrik O.I. 1,3
Affiliations
1 (Данные Web of science) Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, 8 Prosp Acad Lavrenteva, Novosibirsk 630090, Russia
2 (Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Prosp Acad Lavrenteva, Novosibirsk 630090, Russia
3 (Данные Web of science) Novosibirsk State Univ, 2 Pirogova St, Novosibirsk 630090, Russia

Abstract: Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) fell in the range IC50 = 5.5-7.1 mu M.
Cite: Zakharenko A.L. , Mozhaitsev E.S. , Suslov E.V. , Korchagina D.V. , Volcho K.P. , Salakhutdinov N.F. , Lavrik O.I.
SYNTHESIS AND INHIBITORY PROPERTIES OF IMINES CONTAINING MONOTERPENOID AND ADAMANTANE FRAGMENTS AGAINST DNA REPAIR ENZYME TYROSYL-DNA PHOSPHODIESTERASE 1 (Tdp1)
Chemistry of Natural Compounds. 2018. V.54. N4. P.672-676. DOI: 10.1007/s10600-018-2443-7 WOS Scopus РИНЦ OpenAlex
Dates:
Published print: Jul 1, 2018
Published online: Jul 25, 2018
Identifiers:
Web of science: WOS:000440423000013
Scopus: 2-s2.0-85050668291
Elibrary: 35754948
OpenAlex: W2883821358
Citing:
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Web of science 5
Scopus 5
Elibrary 6
OpenAlex 5
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