Globular chitosan treatment of bovine jugular veins: evidence of anticalcification efficacy in the subcutaneous rat model Научная публикация
| Журнал |
Cardiovascular Pathology
ISSN: 1054-8807 , E-ISSN: 1879-1336 |
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| Вых. Данные | Год: 2018, Том: 32, Страницы: 1-7 Страниц : 7 DOI: 10.1016/j.carpath.2017.08.003 | ||||||
| Ключевые слова | Globular chitosan; Calcification of vascular xenografts; Bovine jugular vein; Subcutaneous rat model; Decellularization | ||||||
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| Организации |
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Реферат:
Vascular xenografts are widely used in cardiovascular surgery as an alternative to autologous vessels and vascular allografts. Calcification is one of the main drawbacks of vascular grafts, especially among young patients and children. Among different anticalcification approaches, chitosan emerges as a highly promising candidate clue to its versatility, natural origin, and biocompatibility. We investigated the anticalcification efficacy of globular chitosan ("Chitozol") as it demonstrated the improved rate of water solubility as compared with conventional linear macromolecules of chitosan. In addition, we supposed that compact globular form of "Chitozol" molecules could provide effective penetration of extracellular matrix of bovine jugular veins (BJVs). Our results revealed that "Chitozol" treatment mitigated calcification in the experimental groups as compared to the control groups (without any treatment, conventional treatment with glutaraldehyde, and commercially available Contegra conduit). Different concentrations of "Chitozol" (0.3% and 3%), as well as different incubation times (15 and 30 min), were equally effective in the prevention of calcification. In addition, "Chitozol" treatment with decellularization of BJVs demonstrated slightly improved stress-strain properties of unimplanted samples. Thus, the filling of fresh 131V with globular chitosan is proposed as a promising emerging treatment for the mitigation of calcific degeneration in BJVs xenografts. (C) 2017 Elsevier Inc. All rights reserved.
Библиографическая ссылка:
Krasilnikova A.A.
, Sergeevichev D.S.
, Fomenko V.V.
, Korobeynikov A.A.
, Vasilyeva M.B.
, Yunoshev A.S.
, Karaskov A.M.
, Pokushalov E.A.
Globular chitosan treatment of bovine jugular veins: evidence of anticalcification efficacy in the subcutaneous rat model
Cardiovascular Pathology. 2018. V.32. P.1-7. DOI: 10.1016/j.carpath.2017.08.003 WOS Scopus РИНЦ OpenAlex
Globular chitosan treatment of bovine jugular veins: evidence of anticalcification efficacy in the subcutaneous rat model
Cardiovascular Pathology. 2018. V.32. P.1-7. DOI: 10.1016/j.carpath.2017.08.003 WOS Scopus РИНЦ OpenAlex
Даты:
| Опубликована в печати: | 1 янв. 2018 г. |
Идентификаторы БД:
| Web of science: | WOS:000419095700001 |
| Scopus: | 2-s2.0-85031739064 |
| РИНЦ: | 31124800 |
| OpenAlex: | W2754428064 |