Abstract: Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, the lifetime risk of developing this disease is 1.5%. Motor diagnostic symptoms of PD are caused by degeneration of nigrostriatal dopamine neurons. There is no cure for PD and current therapy is limited to supportive care that partially alleviates disease signs and symptoms. As diagnostic symptoms of PD result from progressive degeneration of dopamine neurons, drugs restoring these neurons may significantly improve treatment of PD. Method: A literature search was performed using the PubMed, Web of Science and Scopus data-bases to discuss the progress achieved in the development of neuroregenerative agents for PD. Papers published before early 2018 were taken into account. Results: Here, we review several groups of potential agents capable of protecting and restoring dopamine neurons in cultures or animal models of PD including neurotrophic factors and small molecular weight compounds. Conclusion: Despite the promising results of in vitro and in vivo experiments, none of the found agents have yet shown conclusive neurorestorative properties in PD patients. Meanwhile, a few promising biologicals and small molecules have been identified. Their further clinical development can eventually give rise to disease-modifying drugs for PD. Thus, intensive research in the field is justified.

Cite: Sidorova Y.A. , Volcho K.P. , Salakhutdinov N.F.
Neuroregeneration in Parkinson's Disease: From Proteins to Small Molecules
Current Neuropharmacology. 2019. V.17. N3. P.268-287. DOI: 10.2174/1570159X16666180905094123 WOS Scopus РИНЦ OpenAlex

Files: Full text from publisher

Dates:

Published print:

Feb 14, 2019

Identifiers:

Web of science:	WOS:000458614000006
Scopus:	2-s2.0-85062087375
Elibrary:	41789061
OpenAlex:	W2890873042

Citing:

DB	Citing
Web of science	26
Scopus	30
Elibrary	23
OpenAlex	29

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