Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo

Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo Full article

Journal

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Output data

Year: 2017, Volume: 164, Number: 1, Pages: 49-53 Pages count : 5 DOI: 10.1007/s10517-017-3924-6

Tags

alkoxyamines; toxicity; tumor cell lines; transplanted tumor strains; phagocytic activity of peritoneal macrophages

Authors

Popova N.A. ¹ , Sysoeva G.M. ² , Nikolin V.P. ¹ , Kaledin V.I. ¹ , Tretyakov E.V. ³ , Edeeva M.V. ³ , Balakhnin S.M. ⁴ , Lushnikova E.L. ⁴ , Audran G. ⁵ , Mark S. ³

Affiliations

1	(Данные Web of science) Russian Acad Sci, Fed Res Inst Cytol & Genet, Siberian Div, Novosibirsk, Russia
2	(Данные Web of science) Vektor State Res Ctr Virol & Biotechnol, Inst Med Biotechnol, Koltsov, Novosibirsk Reg, Russia
3	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Div, Moscow, Russia
4	(Данные Web of science) Inst Mol Pathol & Pathomorphol, Novosibirsk, Russia
5	(Данные Web of science) Aix Marseille Univ, Aix En Provence, France

Effect of alkoxyamines on normal and tumor cells was studied in vitro and in vivo. In vitro experiments showed that alkoxyamines produce a dose-dependent toxic effect on cells of human breast tumor MCF7 line. Transplantation of Krebs-2 ascites carcinoma cells preincubated with alkoxyamines to mice did not induce tumor growth. An opposite effect was observed in normal mouse cells: functional activity of peritoneal macrophages increased. The possibility of using alkoxyamines as theranostic agents is discussed.

Popova N.A. , Sysoeva G.M. , Nikolin V.P. , Kaledin V.I. , Tretyakov E.V. , Edeeva M.V. , Balakhnin S.M. , Lushnikova E.L. , Audran G. , Mark S.
Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo
Bulletin of Experimental Biology and Medicine. 2017. V.164. N1. P.49-53. DOI: 10.1007/s10517-017-3924-6 WOS Scopus РИНЦ OpenAlex

Низомов С.А. , Сорокина И.В. , Жукова Н.А. , Толстикова Т.Г. , Семенов Д.Е. , Просенко А.Е.
Сравнительное исследование токсичности алкоксиаминов in vitro и in vivo
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2017. Т.164. №7. С.61-65. РИНЦ

Published print:	Nov 1, 2017
Published online:	Nov 9, 2017

Web of science:	WOS:000415613100013
Scopus:	2-s2.0-85033378169
Elibrary:	31044534
OpenAlex:	W2767556561

DB	Citing
Web of science	11
Scopus	8
Elibrary	9
OpenAlex	9