Methylation of 2,6-di-tert-butylphenol with methanol-d4 in the presence of zinc oxide and bases. Hydrogen-deuterium exchange in the ortho-tert-butyl groups with the medium

Methylation of 2,6-di-tert-butylphenol with methanol-d4 in the presence of zinc oxide and bases. Hydrogen-deuterium exchange in the ortho-tert-butyl groups with the medium Full article

Journal

Russian Journal of Organic Chemistry
ISSN: 1070-4280 , E-ISSN: 1608-3393

Output data

Year: 2000, Volume: 36, Number: 1, Pages: 72-78 Pages count : 7

Authors

Krysin A.P. ¹ , Pokrovskii L.M. ¹ , Shakirov M.M. ¹

Affiliations

1	(Scopus) Vorozhtsov Novosibirsk Inst. of O., Siberian Division, Russian Academy of Sciences, pr. Akademika Lavrent'eva 9, Novosibirsk, 630090, Russian Federation

2,6-Di-tert-butyl-4-methylphenol is formed in high yield by reaction of 2,6-di-tert-butylphenol with methanol in the presence of alkali and ZnO. In the reaction with methanol-d4, the deuteromethylation process is accompanied by hydrogen-deuterium exchange in the tert-butyl groups. With 2,4,6-tri-tert-butylphenol as an example, the isotope exchange was shown to involve only the tert-butyl groups located ortho with respect to the hydroxy group. Conditions were found for replacement of hydrogen in position 4 of 2,6-di-tert-butylphenol by deuterium.

Krysin A.P. , Pokrovskii L.M. , Shakirov M.M.
Methylation of 2,6-di-tert-butylphenol with methanol-d4 in the presence of zinc oxide and bases. Hydrogen-deuterium exchange in the ortho-tert-butyl groups with the medium
Russian Journal of Organic Chemistry. 2000. V.36. N1. P.72-78. Scopus РИНЦ

Krysin A. , Pokrovskii L. , Shakirov M.
Methylation of 2,6-Di-tert-butylphenol by perdeuteromethanol in the presence of zinc oxide and bases and an isotopic exchange of hydrogen atoms of ortho-tret-butyl groups with media
Журнал органической химии (RUSS J ORG CHEM+). 2000. V.36. N1. P.79-86. WOS

Scopus:	2-s2.0-0033634552
Elibrary:	13344942

Пока нет цитирований