The toxic action of a new phenolic antioxidant SO-3 studied in a subchronic experiment Full article
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Экспериментальная и клиническая фармакология/Eksperimental'naya i Klinicheskaya Farmakologiya
ISSN: 0869-2092 |
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| Output data | Year: 2000, Volume: 63, Number: 4, Pages: 60- Pages count : | ||
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Abstract:
Subchronic tests on rats showed that a new phenolic antioxidant bis[3,(3, 5-di-tert-butyl-4-hydroxyphenyl)propyl] sulfide (SO-3) exhibits low toxicity upon peroral administration. Neither significant variations in the hematological and integral indices, nor pathological shifts in the activity of serum enzymes or pathomorphological changes in the internal organs were observed. Simultaneous administration of a sunflower oil with SO-3 led to a significant decrease in the blood cholesterol level, produced a hepatoprotector effect, and exhibited a protective action with respect to the mucous membranes of the gastrointestinal tract. Animals receiving large doses of SO-3 showed no signs of a prelipid stage of the arteriosclerosis typically observed in the control group.
Cite:
Voevoda T.V.
, Tolstikova T.G.
, Sorokina I.V.
, Dolgikh M.P.
, Orlova T.N.
The toxic action of a new phenolic antioxidant SO-3 studied in a subchronic experiment
Экспериментальная и клиническая фармакология/Eksperimental'naya i Klinicheskaya Farmakologiya. 2000. V.63. N4. P.60-. Scopus РИНЦ
The toxic action of a new phenolic antioxidant SO-3 studied in a subchronic experiment
Экспериментальная и клиническая фармакология/Eksperimental'naya i Klinicheskaya Farmakologiya. 2000. V.63. N4. P.60-. Scopus РИНЦ
Identifiers:
| Scopus: | 2-s2.0-0042185626 |
| Elibrary: | 14952215 |