Psychotropic properties of the alkaloid lappaconitine and some of its derivatives

Psychotropic properties of the alkaloid lappaconitine and some of its derivatives Full article

Journal

Экспериментальная и клиническая фармакология/Eksperimental'naya i Klinicheskaya Farmakologiya
ISSN: 0869-2092

Output data

Year: 2001, Volume: 64, Number: 4, Pages: 9- Pages count :

Authors

Tolstikova T. G. , Voevoda T. V. , Dolgikh M. P.

Affiliations

1	(Scopus) Dept. Nat. Biologically Active C., Vorozhtsov Inst. of Organ. Chemistry, Russian Academy of Sciences, pr. akad. Lavrent'eva 9, Novosibirsk, 630090, Russian Federation

The psychotropic activity of (I, base), its N-oxide, and a complex of the base with 18-α-H-glycyrrhizic acid (1 : 2) was studied. It was established that I and its N-oxide exhibit dopaminopositive effect whereas the complex produces a serotoninopositive effect. Toxicities of the lipophilic I is half that of the hydrophilic; toxicity of N-oxide and the complex are 60 and 100 times lower than the activity of lappaconitine (base).

Tolstikova T.G. , Voevoda T.V. , Dolgikh M.P.
Psychotropic properties of the alkaloid lappaconitine and some of its derivatives
Экспериментальная и клиническая фармакология/Eksperimental'naya i Klinicheskaya Farmakologiya. 2001. V.64. N4. P.9-. Scopus

Scopus:

2-s2.0-0042696268

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