Halogenated (F, Cl) 1,3-benzodiazoles, 1,2,3-benzotriazoles, 2,1,3-benzothia(selena)diazoles and 1,4-benzodiazines inducing Hep2 cell apoptosis

Halogenated (F, Cl) 1,3-benzodiazoles, 1,2,3-benzotriazoles, 2,1,3-benzothia(selena)diazoles and 1,4-benzodiazines inducing Hep2 cell apoptosis Full article

Journal

Mendeleev Communications
ISSN: 0959-9436

Output data

Year: 2017, Volume: 27, Number: 5, Pages: 439-442 Pages count : 4 DOI: 10.1016/j.mencom.2017.09.002

Authors

Prima Darya O. ^1,2 , Vorontsova Elena V. ³ , Makarov Arkady G. ¹ , Makarov Alexander Yu. ¹ , Bagryanskaya Irina Yu. ^1,4 , Mikhailovskaya Tatiana F. ¹ , Slizhov Yuri G. ² , Zibarev Andrey V. ^1,2

Affiliations

1	(Данные Web of science) Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
2	(Данные Web of science) Tomsk State Univ, Dept Chem, Tomsk 634050, Russia
3	(Данные Web of science) Russian Acad Sci, Inst Mol Biol & Biophys, Siberian Branch, Novosibirsk 630117, Russia
4	(Данные Web of science) Novosibirsk State Univ, Dept Nat Sci, Novosibirsk 630090, Russia

The title compounds synthesized from halogenated arene-1,2-diamines revealed, together with the latter, cytotoxicity towards the Hep2 (laryngeal epidermoid carcinoma) cells. The cytotoxicity was high and was accompanied by pronounced apoptotic activity at low concentrations for fluorinated diazoles, triazoles and selenadiazoles.

Prima D.O. , Vorontsova E.V. , Makarov A.G. , Makarov A.Y. , Bagryanskaya I.Y. , Mikhailovskaya T.F. , Slizhov Y.G. , Zibarev A.V.
Halogenated (F, Cl) 1,3-benzodiazoles, 1,2,3-benzotriazoles, 2,1,3-benzothia(selena)diazoles and 1,4-benzodiazines inducing Hep2 cell apoptosis
Mendeleev Communications. 2017. V.27. N5. P.439-442. DOI: 10.1016/j.mencom.2017.09.002 WOS Scopus РИНЦ OpenAlex

Published print:

Sep 1, 2017

Web of science:	WOS:000413618800002
Scopus:	2-s2.0-85030125084
Elibrary:	31100771
OpenAlex:	W2757424886

DB	Citing
Web of science	20
Scopus	21
Elibrary	19
OpenAlex	21