Two directions of the reaction of 4-bromobenzaldehyde with substituted acetophenones and urea. Synthesis of aryl-substituted pyrimidin-2-one and hexahydropyrimido[4,5-d]pyrimidin-2,7-dione Full article
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Chemistry of Heterocyclic Compounds
ISSN: 0009-3122 , E-ISSN: 1573-8353 |
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| Output data | Year: 2004, Volume: 40, Number: 2, Pages: 194-202 Pages count : 9 DOI: 10.1023/B:COHC.0000027891.72906.c7 | ||
| Tags | 4,6-diaryl-1H-pyrimidin-2-ones; 4-alkylacetophenones; 4-bromoacetaldehyde; 5-bromo-1H-pyrimidin-2-ones; Aminopyrimidines; Bromination; Chloropyrimidines; Condensation; Hexahydro-1H,8H-pyrimido[4,5-d]pyrimidin-2,7-diones | ||
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Abstract:
Condensation of 4-bromobenzaldehyde, urea, and 4-alkyl-substituted acetophenones gave substituted hexahydro-1H,8H-pyrimido[4,5-d]pyrimidin-2,7- diones or 1H-pyrimidin-2-ones, depending on the substituent on the acetophenone ring and the nature of the solvent (i-PrOH, BuOH, AcOH). The corresponding 5-bromopyrimidin-2-ones were formed on bromination of these compounds. The structures of these compounds were confirmed by IR, UV, and 1H NMR spectroscopy.
Cite:
Sedova V.F.
, Shkurko O.P.
Two directions of the reaction of 4-bromobenzaldehyde with substituted acetophenones and urea. Synthesis of aryl-substituted pyrimidin-2-one and hexahydropyrimido[4,5-d]pyrimidin-2,7-dione
Chemistry of Heterocyclic Compounds. 2004. V.40. N2. P.194-202. DOI: 10.1023/B:COHC.0000027891.72906.c7 Scopus РИНЦ OpenAlex
Two directions of the reaction of 4-bromobenzaldehyde with substituted acetophenones and urea. Synthesis of aryl-substituted pyrimidin-2-one and hexahydropyrimido[4,5-d]pyrimidin-2,7-dione
Chemistry of Heterocyclic Compounds. 2004. V.40. N2. P.194-202. DOI: 10.1023/B:COHC.0000027891.72906.c7 Scopus РИНЦ OpenAlex
Dates:
| Published print: | Feb 1, 2004 |
Identifiers:
| Scopus: | 2-s2.0-3343006468 |
| Elibrary: | 13464419 |
| OpenAlex: | W2951959864 |