Diazabicycloalkanes with nitrogen atoms in the nodal positions. 8. Effect of c-substituents on the N-methylation of 1,4-diazabi cyclo[2.2.2]octanes and the demethylation of their bisquaternary salts Full article
| Journal |
Chemistry of Heterocyclic Compounds
ISSN: 0009-3122 , E-ISSN: 1573-8353 |
||
|---|---|---|---|
| Output data | Year: 1982, Volume: 18, Number: 2, Pages: 196-201 Pages count : DOI: 10.1007/BF00512969 | ||
| Authors |
|
||
| Affiliations |
|
Abstract:
The introduction of substituents with various inductive constants in the 2 position of the diazabicyclo]2.2.2]octane ring gives rise to a change in the pKa values and affects the ease of introduction of a methyl group in the 1 and 4 positions, as well as the rate of demethylation of the bisquaternary salts from the 1 position. When 1,4-diazabicyclo[2.2.2]octane is treated with a sufficiently strong nucleophile, the ring is opened to give a piperazine derivative. © 1982 Plenum Publishing Corporation.
Cite:
Vysochin V.I.
, Shishkin G.V.
Diazabicycloalkanes with nitrogen atoms in the nodal positions. 8. Effect of c-substituents on the N-methylation of 1,4-diazabi cyclo[2.2.2]octanes and the demethylation of their bisquaternary salts
Chemistry of Heterocyclic Compounds. 1982. V.18. N2. P.196-201. DOI: 10.1007/BF00512969 Scopus РИНЦ OpenAlex
Diazabicycloalkanes with nitrogen atoms in the nodal positions. 8. Effect of c-substituents on the N-methylation of 1,4-diazabi cyclo[2.2.2]octanes and the demethylation of their bisquaternary salts
Chemistry of Heterocyclic Compounds. 1982. V.18. N2. P.196-201. DOI: 10.1007/BF00512969 Scopus РИНЦ OpenAlex
Dates:
| Published print: | Feb 1, 1982 |
Identifiers:
| Scopus: | 2-s2.0-34250230197 |
| Elibrary: | 30843405 |
| OpenAlex: | W2950169762 |