Anti-influenza activity of monoterpene-containing substituted coumarins

Anti-influenza activity of monoterpene-containing substituted coumarins Full article

Journal

Bioorganic and Medicinal Chemistry Letters
ISSN: 0960-894X , E-ISSN: 1464-3405

Output data

Year: 2017, Volume: 27, Number: 13, Pages: 2920-2925 Pages count : 6 DOI: 10.1016/j.bmcl.2017.04.091

Tags

Terpene; Coumarin; Anti-influenza activity; Antivirals; Cytotoxicity; Influenza A virus; Aurapten; Myrtenal

Authors

Khomenko Tatyana M. ^1,3 , Zarubaev Vladimir V. ² , Orshanskaya Iana R. ² , Kadyrova Renata A. ² , Sannikova Victoria A. ^1,3 , Korchagina Dina V. ¹ , Volcho Konstantin P. ^1,3 , Salakhutdinov Nariman F. ^1,3

Affiliations

1	(Данные Web of science) Russian Acad Sci, Siberian Branch, Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
2	(Данные Web of science) Influenza Res Inst, Dept Chemotherapy, 15-17 Prof Popova St, St Petersburg 197376, Russia
3	(Данные Web of science) Novosibirsk State Univ, Pirogova 2, Novosibirsk 630090, Russia

Compounds simultaneously carrying the monoterpene and coumarin moieties have been tested for cytotoxicity and inhibition of activity against influenza virus A/California/07/09 (H1N1) pdm09. The structure of substituents in the coumarin framework, as well as the structure and the absolute configuration of the monoterpenoid moiety, are shown to significantly influence the anti-influenza activity and cytotoxicity of the compounds under study. The compounds with a bicyclic pinane framework exhibit the highest selectivity indices (the ratios between the cytotoxicity and the active dose). The derivative of (-)-myrtenol 15c, which is characterized by promising activity, low cytotoxicity, and synthetic accessibility, has the greatest potential among this group of compounds. It exhibited the highest activity when added to the infected cell culture at early stages of viral reproduction. (C) 2017 Elsevier Ltd. All rights reserved.

Khomenko T.M. , Zarubaev V.V. , Orshanskaya I.R. , Kadyrova R.A. , Sannikova V.A. , Korchagina D.V. , Volcho K.P. , Salakhutdinov N.F.
Anti-influenza activity of monoterpene-containing substituted coumarins
Bioorganic and Medicinal Chemistry Letters. 2017. V.27. N13. P.2920-2925. DOI: 10.1016/j.bmcl.2017.04.091 WOS Scopus РИНЦ OpenAlex

Published print:

Jul 1, 2017

Web of science:	WOS:000402470600016
Scopus:	2-s2.0-85019144448
Elibrary:	31026555
OpenAlex:	W2607788412

DB	Citing
Web of science	36
Scopus	39
Elibrary	40
OpenAlex	38