Synthesis and analgesic activity of monoterpenoid-derived alkyl-substituted chiral hexahydro-2H-chromenes Full article
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Medicinal Chemistry Research
ISSN: 1054-2523 , E-ISSN: 1554-8120 |
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| Output data | Year: 2017, Volume: 26, Number: 7, Pages: 1415-1426 Pages count : 12 DOI: 10.1007/s00044-017-1847-4 | ||||
| Tags | Terpene; Chromene; Heterocyclic compounds; Analgesic activity; Acetic acid-induced writhing test; Hot-plate test | ||||
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Abstract:
A set of new 2-alkyl-substituted 4,7-dimethyl-3,4,4a,5,8,8a-hexahydro-2H-chromene-4,8-diols was obtained by reactions of monoterpenoid (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol with aliphatic aldehydes in the presence of montmorillonite clay K10. Synthesized compounds were evaluated for their analgesic activity in vivo using the acetic acid-induced writhing test and the hot-plate test. Five compounds showed a significant analgesic activity in the acetic acid-induced writhing test; two of them also demonstrated analgesic activity in the hot-plate test. These compounds seem to be most promising for further development.
Cite:
Il'ina I.
, Pavlova A.
, Korchagina D.
, Ardashov O.
, Tolstikova T.
, Volcho K.
, Salakhutdinov N.
Synthesis and analgesic activity of monoterpenoid-derived alkyl-substituted chiral hexahydro-2H-chromenes
Medicinal Chemistry Research. 2017. V.26. N7. P.1415-1426. DOI: 10.1007/s00044-017-1847-4 WOS Scopus РИНЦ OpenAlex
Synthesis and analgesic activity of monoterpenoid-derived alkyl-substituted chiral hexahydro-2H-chromenes
Medicinal Chemistry Research. 2017. V.26. N7. P.1415-1426. DOI: 10.1007/s00044-017-1847-4 WOS Scopus РИНЦ OpenAlex
Dates:
| Published online: | Mar 17, 2017 |
| Published print: | Jul 1, 2017 |
Identifiers:
| Web of science: | WOS:000402397700009 |
| Scopus: | 2-s2.0-85015694352 |
| Elibrary: | 31034953 |
| OpenAlex: | W2595695761 |