Pyrimidines - XV. Substituted 2, 2′-dioxo-6, 6′-spirobishexahydropyrimidines

Pyrimidines - XV. Substituted 2, 2′-dioxo-6, 6′-spirobishexahydropyrimidines Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 0009-3122 , E-ISSN: 1573-8353

Output data

Year: 1971, Volume: 4, Number: 5, Pages: 667-671 Pages count : 5 DOI: 10.1007/BF00481053

Authors

Sedova V.F. ¹ , Mamaev V.M. ¹

Affiliations

1	(Scopus) Siberian Division AS USSR, Institute of Organic Chemistry, Novosibirsk, Russian Federation

The reaction of cyclohexanone with arylidenebisureas (e.g. benzal-bisurea) in an acid medium has given 4, 4′-diaryl-2, 2′-dioxo-5, 5′-trimethylene-6, 6′-spirobishexahydropyrimidines (II). The acid hydrolysis of IIa (aryl-C6H5) in the presence of 2, 4-dinitrophenylhydrazine leads to the 2, 4-dinitrophenylhydrazone of 2-hydroxy-8-oxo-4-phenyl-5, 6, 7, 8-tetrahydroquinazoline (IV). Compound IV was also obtained by the ozonization of 2-acetoxy-8-benzal-4-phenyl-5, 6, 7, 8-tetrahydroquinazoline (IX) and subsequent decomposition of the ozonide with a solution of 2, 4-dinitrophenylhydrazine. The structure of the compounds obtained was confirmed by means of their IR, UV, and PMR spectra. Corresponding 6, 6′-spirobishexahydropyrimidines have also been obtained from 2-methylcyclohexanone, acetone, and methyl ethyl ketone and benzalbisurea. © 1971 Consultants Bureau.

Sedova V.F. , Mamaev V.M.
Pyrimidines - XV. Substituted 2, 2′-dioxo-6, 6′-spirobishexahydropyrimidines
Chemistry of Heterocyclic Compounds. 1971. V.4. N5. P.667-671. DOI: 10.1007/BF00481053 Scopus РИНЦ OpenAlex

Scopus:	2-s2.0-34250475242
Elibrary:	30875266
OpenAlex:	W2317655812

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