Synthesis and analgesic activity of pyrrolidinomorphinan derivatives Full article
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Pharmaceutical Chemistry Journal
ISSN: 0091-150X , E-ISSN: 1573-9031 |
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| Output data | Year: 2007, Volume: 41, Number: 2, Pages: 74-77 Pages count : 4 DOI: 10.1007/s11094-007-0016-3 | ||
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Abstract:
Diels-Alder reactions of (-)-thebaine with N-substituted maleimides have been used to obtain cycloadducts possessing α-facial stereoselectivity. The 3-O-and 6-O-demethylated derivatives as well as the products of complete and partial reduction of carbonyl groups in the pyrrolidinedione moiety were also obtained. Some of the synthesized compounds have proved to be promising analgesics. The introduction of the bromine atom into the aryl moiety favors prolongation of the analgesic effect. © 2007 Springer Science+Business Media, Inc.
Cite:
Shul'ts E.E.
, Tolstikova T.G.
, Tolstikov S.E.
, Daibova V.T.
, Shakirov M.M.
, Bolkunov A.V.
, Dolgikh M.P.
Synthesis and analgesic activity of pyrrolidinomorphinan derivatives
Pharmaceutical Chemistry Journal. 2007. V.41. N2. P.74-77. DOI: 10.1007/s11094-007-0016-3 Scopus РИНЦ OpenAlex
Synthesis and analgesic activity of pyrrolidinomorphinan derivatives
Pharmaceutical Chemistry Journal. 2007. V.41. N2. P.74-77. DOI: 10.1007/s11094-007-0016-3 Scopus РИНЦ OpenAlex
Original:
Шульц Э.Э.
, Толстикова Т.Г.
, Толстиков С.Е.
, Дайбова В.Т.
, Шакиров М.М.
, Болкунов А.В.
, Долгих М.П.
Синтез и анальгетическая активность производных пирролидиноморфинана
Химико-фармацевтический журнал (PHARM CHEM J+). 2007. Т.41. №2. С.15-18. РИНЦ
Синтез и анальгетическая активность производных пирролидиноморфинана
Химико-фармацевтический журнал (PHARM CHEM J+). 2007. Т.41. №2. С.15-18. РИНЦ
Dates:
| Published print: | Feb 1, 2007 |
Identifiers:
| Scopus: | 2-s2.0-34548575044 |
| Elibrary: | 13557631 |
| OpenAlex: | W1979179085 |