Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus Full article
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MedChemComm
ISSN: 2040-2503 , E-ISSN: 2040-2511 |
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| Output data | Year: 2017, Volume: 8, Number: 5, Pages: 960-963 Pages count : 4 DOI: 10.1039/c6md00657d | ||||||
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Abstract:
Herein, we present the design and synthesis of a series of novel heterocyclic derivatives of (-)-borneol and (-)-isoborneol as potent inhibitors of the influenza A virus. All compounds were tested for their toxicity against MDCK cells and for virus-inhibiting activity against the influenza virus A/Puerto Rico/8/34 (H1N1). Compounds 7, 16 and 26 containing a morpholine fragment exhibited the highest efficiency as agents inhibiting the replication of the influenza virus A(H1N1) with selectivity indices of 82, 45 and 65, correspondingly. Derivatives 9 (SI = 23) and 18 (SI = 25) containing a 1-methylpiperazine motif showed moderate antiviral activity. Structure-activity analysis of this new series of borneol derivatives revealed that a 1,7,7-trimethylbicyclo[2.2.1] heptan scaffold is required for the antiviral activity.
Cite:
Sokolova A.S.
, Yarovaya O.I.
, Semenova M.D.
, Shtro A.A.
, Orshanskaya I.R.
, Zarubaev V.V.
, Salakhutdinov N.F.
Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus
MedChemComm. 2017.
V.8. N5. P.960-963. DOI: 10.1039/c6md00657d
WOS
Scopus
РИНЦ
OpenAlex
Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus
MedChemComm. 2017.
V.8. N5. P.960-963. DOI: 10.1039/c6md00657d
WOS
Scopus
РИНЦ
OpenAlex
Files:
Full text from publisher
Identifiers:
| Web of science: | WOS:000402049300013 |
| Scopus: | 2-s2.0-85021957010 |
| Elibrary: | 31056942 |
| OpenAlex: | W2593166645 |