Improvement of pharmacological values of the nifedipine by means of mechanochemical complexation with glycyrrhizic acid Научная публикация
| Журнал |
Biomeditsinskaya Khimiya
ISSN: 2310-6905 |
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| Вых. Данные | Год: 2010, Том: 56, Номер: 2, Страницы: 187-194 Страниц : DOI: 10.18097/pbmc20105602187 | ||||
| Ключевые слова | Complexation; Glycosides; Glycyrrhizic acid; Nifedipine | ||||
| Авторы |
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| Организации |
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Реферат:
A new water-soluble form of the calcium blocker nifedipine (NF) with glycyrrtrizic acid (GA) (with molecular ratio 1:4) has been obtained by mechanochemical synthesis. Its pharmacological advantages in comparison with nifedipine were determined. An effective dose of nifedipine in complex reduced to 10 times as compared to its therapeutic dose while high antihypertensive activity preservation and pleiotropic antiarhythmic activity enhancement. This new antihypertensive and antiarhythmic agent (complex of NF:GA = 1:4) is chemically stable and safe for parenteral administration.
Библиографическая ссылка:
Tolstikova T.G.
, Khvostov M.V.
, Bryzgalov A.O.
, Dushkin A.V.
, Meteleva E.S.
Improvement of pharmacological values of the nifedipine by means of mechanochemical complexation with glycyrrhizic acid
Biomeditsinskaya Khimiya. 2010.
V.56. N2. P.187-194. DOI: 10.18097/pbmc20105602187
Scopus
OpenAlex
Improvement of pharmacological values of the nifedipine by means of mechanochemical complexation with glycyrrhizic acid
Biomeditsinskaya Khimiya. 2010.
V.56. N2. P.187-194. DOI: 10.18097/pbmc20105602187
Scopus
OpenAlex
Файлы:
Полный текст от издателя
Даты:
| Опубликована в печати: | 1 мар. 2010 г. |
Идентификаторы БД:
| Scopus: | 2-s2.0-77953017561 |
| OpenAlex: | W2405340757 |