Lappaconitine: Influence of halogen substituent on the antiarrhythmic activity Full article
| Journal |
Cardiovascular and Hematological Agents in Medicinal Chemistry
ISSN: 1871-5257 |
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| Output data | Year: 2013, Volume: 11, Number: 3, Pages: 211-217 Pages count : DOI: 10.2174/18715257113119990083 | ||
| Tags | Arrhythmia; Halogen-containing lappaconitine derivatives; Lappaconitine | ||
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Abstract:
The current paper presents research results related to antiarrhythmic activity of halogen-containing derivatives of lappaconitine. Lappaconitine derivatives with iodine, chlorine or bromine substituting the anthranilate moiety at C-5' position were shown in vivo and in vitro to exhibit a more (Br, I) or less (Cl) pronounced antiarrhythmic activity in the models of calcium chloride- and adrenaline-induced arrhythmias as compared with the reference compound lappaconitine. The intensity of antiarrhythmic action depending on halogen substituent was found to be expressed by the following order: Cl < I < Br. © 2013 Bentham Science Publishers.
Cite:
Bryzgalov A.O.
, Romanov V.E.
, Tolstikova T.G.
, Shults E.E.
Lappaconitine: Influence of halogen substituent on the antiarrhythmic activity
Cardiovascular and Hematological Agents in Medicinal Chemistry. 2013. V.11. N3. P.211-217. DOI: 10.2174/18715257113119990083 Scopus РИНЦ OpenAlex
Lappaconitine: Influence of halogen substituent on the antiarrhythmic activity
Cardiovascular and Hematological Agents in Medicinal Chemistry. 2013. V.11. N3. P.211-217. DOI: 10.2174/18715257113119990083 Scopus РИНЦ OpenAlex
Dates:
| Published print: | Jan 31, 2014 |
Identifiers:
| Scopus: | 2-s2.0-84892958801 |
| Elibrary: | 21909441 |
| OpenAlex: | W2063757150 |