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Oxygen-induced leakage of spin polarization in Overhauser-enhanced magnetic resonance imaging: Application for oximetry in tumors Full article

Journal Journal of Magnetic Resonance
ISSN: 1090-7807
Output data Year: 2018, Volume: 297, Pages: 42-50 Pages count : 9 DOI: 10.1016/j.jmr.2018.10.005
Tags Leakage of spin polarization; Overhauser-enhanced magnetic resonance imaging (OMRI); Oximetry; Proton-electron double-resonance imaging (PEDRI); Trityl radical; Tumor tissue oximetry
Authors Gorodetskii A.A. 1,2,3,4 , Eubank T.D. 1,5,6 , Driesschaert B. 1,6,7 , Poncelet M. 1,2 , Ellis E. 5 , Khramtsov V.V. 1,2,6 , Bobko A.A. 1,2,6
Affiliations
1 (Scopus) In Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, United States
2 (Scopus) Department of Biochemistry, West Virginia University, School of Medicine, Morgantown, WV 26506, United States
3 (Scopus) N.N. Voroztsov, Novosibirsk Institute of Organic Chemistry SB RAS, Novosibirsk, 630090, Russian Federation
4 (Scopus) Novosibirsk State University, Novosibirsk, 630090, Russian Federation
5 (Scopus) Department of Microbiology, Immunology & Cell Biology, West Virginia University, School of Medicine, Morgantown, WV 26506, United States
6 (Scopus) Department of Pharmaceutical Sciences, West Virginia University, School of Pharmacy, Morgantown, WV 26506, United States
7 (Scopus) West Virginia University Cancer Institute, Morgantown, WV 26506, United States

Abstract: Overhauser-enhanced Magnetic Resonance Imaging (OMRI) is a double resonance technique applied for oxygen imaging in aqueous samples and biological tissues. In this report, we present an improved OMRI approach of oxygen measurement using the single line “Finland” trityl spin probe. Compared to a traditional approach, we introduced an additional mechanism of leakage of spin polarization due to an interaction of a spin system with oxygen. The experimental comparison of the new approach with an oxygen-dependent leakage factor to a traditional approach performed in phantom samples in vitro, and mouse tumor model in vivo, shows improved accuracy of determination of oxygen and contrast agent concentrations. © 2018 Elsevier Inc.
Cite: Gorodetskii A.A. , Eubank T.D. , Driesschaert B. , Poncelet M. , Ellis E. , Khramtsov V.V. , Bobko A.A.
Oxygen-induced leakage of spin polarization in Overhauser-enhanced magnetic resonance imaging: Application for oximetry in tumors
Journal of Magnetic Resonance. 2018. V.297. P.42-50. DOI: 10.1016/j.jmr.2018.10.005 WOS Scopus РИНЦ OpenAlex
Files: Full text from publisher
Dates:
Published print: Dec 1, 2018
Identifiers:
Web of science: WOS:000453112500006
Scopus: 2-s2.0-85055210775
Elibrary: 38644739
OpenAlex: W2895996507
Citing:
DB Citing
Scopus 5
Web of science 4
OpenAlex 5
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