Abstract: The object of the study - the raw material of Ligularia heterophylla Rupr., collected in 2019 in the Almaty region of the Republic of Kazakhstan. The component compositions of essential oils from the aerial and underground parts of Ligularia heterophylla Rupr., obtained by methods of microwave extraction, as well as traditional hydrodistillation, were studied for the first time. Essential oils represented as mobile liquids from light yellow to green shade with characteristic odors. The component composition was determined by chromato-mass spectrometry on an Agilent 6890 gas chromatograph equipped with a MSD 5973 mass-selective detector. Essential oils obtained by the hydrodistillation method contain mainly monoterpenes, while sesquiterpenes predominate in the essential oils obtained by microwave extraction. The antimicrobial and anti-inflammatory activity of Ligularia heterophylla Rupr. essential oil samples was studied for the first time. The essential oil from the underground part (roots) of Ligularia heterophylla Rupr., obtained by microwave extraction method, at a dose of 25 mg/kg, has a pronounced anti-inflammatory activity, comparable to the drug «Diclofenac sodiumа» in the model of acute exudative reaction. © 2020 Wolters Kluwer Medknow Publications. All rights reserved.

Cite: Makubaeva A.I. , Romanenko E.P. , Adekenov S.M. , Tkachev A.V.
Component composition and biological activity of essential oil of ligularia heterophylla rupr [КОМПОНЕНТНЫЙ СОСТАВ И БИОЛОГИЧЕСКАЯ АКТИВНОСТЬ ЭФИРНОГО МАСЛА LIGULARIA HETEROPHYLLA RUPR]
Annals of Tropical Medicine and Public Health. 2020. N3. P.239-244. DOI: 10.14258/jcprm.2020038243 Scopus OpenAlex

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Published online:

Oct 22, 2020

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Scopus:	2-s2.0-85096799939
OpenAlex:	W3099457560

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