Estimation of Absolute Bioavailability of the Chemical Substance of the Anti-Smallpox Preparation NIOCH-14 in Mice

Estimation of Absolute Bioavailability of the Chemical Substance of the Anti-Smallpox Preparation NIOCH-14 in Mice Full article

Journal

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Output data

Year: 2020, Volume: 170, Number: 2, Pages: 207-210 Pages count : 4 DOI: 10.1007/s10517-020-05034-x

Tags

pharmacokinetics; bioavailability; anti-smallpox preparations; mice

Authors

Mazurkov O.Yu ¹ , Shishkina L.N. ¹ , Bormotov N. ¹ , Skarnovich M.O. ¹ , Serova O.A. ¹ , Mazurkova N.A. ¹ , Chernonosov A.A. ² , Tikhonov A.Ya ³ , Selivanov B.A. ³

Affiliations

1	State Research Center of Virology and Biotechnology “Vector”, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia
2	Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia
3	N. N. Vo-rozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia

We compared absolute bioavailability of the chemical substance of the anti-smallpox preparation NIOCH-14 and chemical compound ST-246 active against orthopoxviruses after oral administration to mice in doses of 10 and 50 mu g/g and intravenous administration to mice in a dose of 2 mu g/g body weight. The absolute bioavailability of NIOCH-14 is comparable with the absolute bioavailability of ST-246.

Mazurkov O.Y. , Shishkina L.N. , Bormotov N. , Skarnovich M.O. , Serova O.A. , Mazurkova N.A. , Chernonosov A.A. , Tikhonov A.Y. , Selivanov B.A.
Estimation of Absolute Bioavailability of the Chemical Substance of the Anti-Smallpox Preparation NIOCH-14 in Mice
Bulletin of Experimental Biology and Medicine. 2020. V.170. N2. P.207-210. DOI: 10.1007/s10517-020-05034-x WOS Scopus OpenAlex

Мазурков О.Ю. , Скурат Л.Н. , Бормотов Н.И. , Скарнович М.О. , Серова О.А. , Мазуркова Н.А. , Черноносов А.А. , Тихонов А.Я. , Селиванов Б.А.
Оценка абсолютной биодоступности химической субстанции противооспенного препарата ниох-14 в экспериментах на мышах
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2020. Т.170. №8. С.173-177. РИНЦ

Published print:	Dec 1, 2020
Published online:	Dec 2, 2020

Web of science:	WOS:000595744200008
Scopus:	2-s2.0-85097013181
OpenAlex:	W3106550930

DB	Citing
Web of science	11
Scopus	13
OpenAlex	15