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New insight into the mechanism of drug release from poly(D,l-lactide) film by electron paramagnetic resonance Full article

Journal Polymers
ISSN: 2073-4360
Output data Year: 2020, Volume: 12, Number: 12, Article number : 3046, Pages count : 21 DOI: 10.3390/polym12123046
Tags Electron paramagnetic resonance; Mathematical model of the release kinetics; Mechanism of drug release; Paramagnetic dopants; Poly(D,L-lactide) films
Authors Chumakova Natalia A. 1 , Golubeva Elena N. 1 , Kuzin Sergey V. 1 , Ivanova Tatiana A. 1 , Grigoriev Igor A. 2 , Kostjuk Sergey V. 3,4,5 , Melnikov Mikhail Ya. 1
Affiliations
1 Department of Chemistry, M.V.Lomonosov Moscow State University, Leninskiye Gory, 1/3, Moscow, 119991, Russian Federation
2 Vorozhtsov Novosibirsk Institute of Organic Chemistry Siberian Branch, Russian Academy of Sciences, Lavrentiev Ave., 9, Novosibirsk, 630090, Russian Federation
3 Department of Chemistry, Belarusian State University, Leningradskaya Str. 14, Minsk, 220006, Belarus
4 Research Institute for Physical Chemical Problems, Belarusian State University, 14 Leningradskaya Str., Minsk, 220006, Belarus
5 Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, 119991, Russian Federation

Abstract: A novel approach based on convolution of the electron paramagnetic resonance (EPR) spectra was used for quantitative study of the release kinetics of paramagnetic dopants from poly(D,L-lactide) films. A non-monotonic dependence of the release rate on time was reliably recorded. The release regularities were compared with the dynamics of polymer structure changes determined by EPR, SEM, and optic microscopy. The data obtained allow for the conclusion that the main factor governing dopant release is the formation of pores connected with the surface. In contrast, the contribution of the dopant diffusion through the polymer matrix is negligible. The dopant release can be divided into two phases: release through surface pores, which are partially closed with time, and release through pores initially formed inside the polymer matrix due to autocatalytic hydrolysis of the polymer and gradually connected to the surface of the sample. For some time, these processes co-occur. The mathematical model of the release kinetics based on pore formation is presented, describing the kinetics of release of various dopants from the polymer films of different thicknesses. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Cite: Chumakova N.A. , Golubeva E.N. , Kuzin S.V. , Ivanova T.A. , Grigoriev I.A. , Kostjuk S.V. , Melnikov M.Y.
New insight into the mechanism of drug release from poly(D,l-lactide) film by electron paramagnetic resonance
Polymers. 2020. V.12. N12. 3046 :1-21. DOI: 10.3390/polym12123046 WOS Scopus РИНЦ OpenAlex
Files: Full text from publisher
Dates:
Published online: Dec 18, 2020
Identifiers:
Web of science: WOS:000603095800001
Scopus: 2-s2.0-85098072260
Elibrary: 45057343
OpenAlex: W3110888745
Citing:
DB Citing
Scopus 9
Web of science 9
Elibrary 12
OpenAlex 13
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