FFA1 (GPR40) Receptor Agonists Based on Phenylpropanoic Acid as Hypoglycemic Agents: Structure–Activity Relationship Full article
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Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620 |
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| Output data | Year: 2020, Volume: 46, Number: 6, Pages: 972-988 Pages count : 17 DOI: 10.1134/S1068162020060151 | ||
| Tags | FFA1; FFA1 receptor agonists; GPR40; hypoglycemic activity; phenylpropanoic acid; type 2 diabetes mellitus | ||
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Abstract:
Abstract: Free fatty acid receptor-1 (FFA1) agonists have been considered for a long time as a potentially new class for the treatment of type 2 diabetes mellitus. Phenylpropanoic acid is the preferred scaffold in the development of FFA1 receptor agonists. This review analyzes the effect of structural fragments of phenylpropanoic acid-based agonists on receptor affinity, selectivity, biocompatibility, and metabolic stability. Current trends in the design of FFA1 receptor agonists are discussed. © 2020, Pleiades Publishing, Ltd.
Cite:
Kuranov S.O.
, Luzina O.A.
, Salakhutdinov N.F.
FFA1 (GPR40) Receptor Agonists Based on Phenylpropanoic Acid as Hypoglycemic Agents: Structure–Activity Relationship
Russian Journal of Bioorganic Chemistry. 2020. V.46. N6. P.972-988. DOI: 10.1134/S1068162020060151 WOS Scopus РИНЦ OpenAlex
FFA1 (GPR40) Receptor Agonists Based on Phenylpropanoic Acid as Hypoglycemic Agents: Structure–Activity Relationship
Russian Journal of Bioorganic Chemistry. 2020. V.46. N6. P.972-988. DOI: 10.1134/S1068162020060151 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Nov 1, 2020 |
| Published online: | Dec 28, 2020 |
Identifiers:
| Web of science: | WOS:000603326600004 |
| Scopus: | 2-s2.0-85098130272 |
| Elibrary: | 45059962 |
| OpenAlex: | W3116915721 |